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A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. T...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070806/ https://www.ncbi.nlm.nih.gov/pubmed/32079357 http://dx.doi.org/10.3390/s20041098 |
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author | Chen, Zheyuan Wright, Christopher Dincel, Onder Chi, Ting-Yen Kameoka, Jun |
author_facet | Chen, Zheyuan Wright, Christopher Dincel, Onder Chi, Ting-Yen Kameoka, Jun |
author_sort | Chen, Zheyuan |
collection | PubMed |
description | For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities. |
format | Online Article Text |
id | pubmed-7070806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70708062020-03-19 A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode Chen, Zheyuan Wright, Christopher Dincel, Onder Chi, Ting-Yen Kameoka, Jun Sensors (Basel) Article For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities. MDPI 2020-02-17 /pmc/articles/PMC7070806/ /pubmed/32079357 http://dx.doi.org/10.3390/s20041098 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Zheyuan Wright, Christopher Dincel, Onder Chi, Ting-Yen Kameoka, Jun A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title_full | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title_fullStr | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title_full_unstemmed | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title_short | A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode |
title_sort | low-cost paper glucose sensor with molecularly imprinted polyaniline electrode |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070806/ https://www.ncbi.nlm.nih.gov/pubmed/32079357 http://dx.doi.org/10.3390/s20041098 |
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