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A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode

For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. T...

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Autores principales: Chen, Zheyuan, Wright, Christopher, Dincel, Onder, Chi, Ting-Yen, Kameoka, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070806/
https://www.ncbi.nlm.nih.gov/pubmed/32079357
http://dx.doi.org/10.3390/s20041098
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author Chen, Zheyuan
Wright, Christopher
Dincel, Onder
Chi, Ting-Yen
Kameoka, Jun
author_facet Chen, Zheyuan
Wright, Christopher
Dincel, Onder
Chi, Ting-Yen
Kameoka, Jun
author_sort Chen, Zheyuan
collection PubMed
description For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities.
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spelling pubmed-70708062020-03-19 A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode Chen, Zheyuan Wright, Christopher Dincel, Onder Chi, Ting-Yen Kameoka, Jun Sensors (Basel) Article For the hundreds of millions of worldwide diabetic patients, glucose test strips are the most important and commonly used tool for monitoring blood glucose levels. Commercial test strips use glucose oxidases as recognition agents, which increases the cost and reduces the durability of test strips. To lower the cost of glucose sensors, we developed a paper-based electrical sensor with molecularly imprinted glucose recognition sites and demonstrated the determination of various glucose concentrations in bovine blood solutions. The sensing electrode is integrated with molecular recognition sites in the conductive polymer. A calibration graph as a function of glucose concentration in aqueous solution was acquired and matched with a correlation coefficient of 0.989. We also demonstrated the determination of the added glucose concentrations ranging from 2.2 to 11.1 mM in bovine blood samples with a linear correlation coefficient of 0.984. This non-enzymatic glucose sensor has the potential to reduce the health care cost of test strips as well as make glucose sensor test strips more accessible to underserved communities. MDPI 2020-02-17 /pmc/articles/PMC7070806/ /pubmed/32079357 http://dx.doi.org/10.3390/s20041098 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Zheyuan
Wright, Christopher
Dincel, Onder
Chi, Ting-Yen
Kameoka, Jun
A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title_full A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title_fullStr A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title_full_unstemmed A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title_short A Low-Cost Paper Glucose Sensor with Molecularly Imprinted Polyaniline Electrode
title_sort low-cost paper glucose sensor with molecularly imprinted polyaniline electrode
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070806/
https://www.ncbi.nlm.nih.gov/pubmed/32079357
http://dx.doi.org/10.3390/s20041098
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