One- and Two-Electron Oxidations of β-Amyloid(25-35) by Carbonate Radical Anion (CO(3)(•−)) and Peroxymonocarbonate (HCO(4)(−)): Role of Sulfur in Radical Reactions and Peptide Aggregation

The β-amyloid (Aβ) peptide plays a key role in the pathogenesis of Alzheimer’s disease. The methionine (Met) residue at position 35 in Aβ C-terminal domain is critical for neurotoxicity, aggregation, and free radical formation initiated by the peptide. The role of Met in modulating toxicological pro...

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Detalles Bibliográficos
Autores principales: Francioso, Antonio, Baseggio Conrado, Alessia, Blarzino, Carla, Foppoli, Cesira, Montanari, Elita, Dinarelli, Simone, Giorgi, Alessandra, Mosca, Luciana, Fontana, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070857/
https://www.ncbi.nlm.nih.gov/pubmed/32093407
http://dx.doi.org/10.3390/molecules25040961

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070857/
https://www.ncbi.nlm.nih.gov/pubmed/32093407
http://dx.doi.org/10.3390/molecules25040961

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