A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb

The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The product...

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Detalles Bibliográficos
Autores principales: Talip, Zeynep, Favaretto, Chiara, Geistlich, Susanne, van der Meulen, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070971/
https://www.ncbi.nlm.nih.gov/pubmed/32093425
http://dx.doi.org/10.3390/molecules25040966
Descripción
Sumario:The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The production status of the imaging nuclide (44)Sc and the therapeutic β(-)-emitter nuclide (161)Tb are compared to their more established counterparts, (68)Ga and (177)Lu according to their targetry, irradiation process, radiochemistry, and quality control aspects. The detailed discussion of these significant issues will help towards the future introduction of these promising radionuclides into drug manufacture for clinical application under Good Manufacturing Practice (GMP).

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