A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb

The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The product...

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Detalles Bibliográficos
Autores principales: Talip, Zeynep, Favaretto, Chiara, Geistlich, Susanne, van der Meulen, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070971/
https://www.ncbi.nlm.nih.gov/pubmed/32093425
http://dx.doi.org/10.3390/molecules25040966
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author Talip, Zeynep
Favaretto, Chiara
Geistlich, Susanne
van der Meulen, Nicholas P.
author_facet Talip, Zeynep
Favaretto, Chiara
Geistlich, Susanne
van der Meulen, Nicholas P.
author_sort Talip, Zeynep
collection PubMed
description The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The production status of the imaging nuclide (44)Sc and the therapeutic β(-)-emitter nuclide (161)Tb are compared to their more established counterparts, (68)Ga and (177)Lu according to their targetry, irradiation process, radiochemistry, and quality control aspects. The detailed discussion of these significant issues will help towards the future introduction of these promising radionuclides into drug manufacture for clinical application under Good Manufacturing Practice (GMP).
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spelling pubmed-70709712020-03-19 A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb Talip, Zeynep Favaretto, Chiara Geistlich, Susanne van der Meulen, Nicholas P. Molecules Review The production of novel radionuclides is the first step towards the development of new effective radiopharmaceuticals, and the quality thereof directly affects the preclinical and clinical phases. In this review, novel radiometal production for medical applications is briefly elucidated. The production status of the imaging nuclide (44)Sc and the therapeutic β(-)-emitter nuclide (161)Tb are compared to their more established counterparts, (68)Ga and (177)Lu according to their targetry, irradiation process, radiochemistry, and quality control aspects. The detailed discussion of these significant issues will help towards the future introduction of these promising radionuclides into drug manufacture for clinical application under Good Manufacturing Practice (GMP). MDPI 2020-02-20 /pmc/articles/PMC7070971/ /pubmed/32093425 http://dx.doi.org/10.3390/molecules25040966 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Talip, Zeynep
Favaretto, Chiara
Geistlich, Susanne
van der Meulen, Nicholas P.
A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title_full A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title_fullStr A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title_full_unstemmed A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title_short A Step-by-Step Guide for the Novel Radiometal Production for Medical Applications: Case Studies with (68)Ga, (44)Sc, (177)Lu and (161)Tb
title_sort step-by-step guide for the novel radiometal production for medical applications: case studies with (68)ga, (44)sc, (177)lu and (161)tb
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070971/
https://www.ncbi.nlm.nih.gov/pubmed/32093425
http://dx.doi.org/10.3390/molecules25040966
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