Metronidazole and Secnidazole Carbamates: Synthesis, Antiprotozoal Activity, and Molecular Dynamics Studies

We prepared a series of 10 carbamates derivatives based on two common antiprotozoal drugs: metronidazole (1–5) and secnidazole (6–10). The compounds were tested in vitro against a set of two amitochondriate protozoa: Giardia duodenalis and Trichomonas vaginalis. Compounds 1–10 showed strong antiprot...

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Detalles Bibliográficos
Autores principales: Rocha-Garduño, Genaro, Hernández-Martínez, Norma Angélica, Colín-Lozano, Blanca, Estrada-Soto, Samuel, Hernández-Núñez, Emanuel, Prieto-Martínez, Fernando Daniel, Medina-Franco, José L., Chale-Dzul, Juan Bautista, Moo-Puc, Rosa, Navarrete-Vázquez, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071106/
https://www.ncbi.nlm.nih.gov/pubmed/32059495
http://dx.doi.org/10.3390/molecules25040793

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