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Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats

Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle. Hence, there is a growing interest in the supplementation of phytochemicals to find a safe and effective functional ingredient to treat obesity. Spergularia marina Griseb...

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Autores principales: Park, Yong-Hyun, Lee, Jae-Joon, Son, Hee-Kyoung, Kim, Bok-Hee, Byun, Jaemin, Ha, Jung-Heun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071210/
https://www.ncbi.nlm.nih.gov/pubmed/32012750
http://dx.doi.org/10.3390/nu12020336
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author Park, Yong-Hyun
Lee, Jae-Joon
Son, Hee-Kyoung
Kim, Bok-Hee
Byun, Jaemin
Ha, Jung-Heun
author_facet Park, Yong-Hyun
Lee, Jae-Joon
Son, Hee-Kyoung
Kim, Bok-Hee
Byun, Jaemin
Ha, Jung-Heun
author_sort Park, Yong-Hyun
collection PubMed
description Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle. Hence, there is a growing interest in the supplementation of phytochemicals to find a safe and effective functional ingredient to treat obesity. Spergularia marina Griseb (SM) has traditionally been used as a natural herb against chronic diseases in Korea. In this study, we investigated the antiobesity effects of SM in vitro and in vivo. SM ethanol extract (SME) inhibited proliferation and differentiation in murine adipocytes and primary porcine pre-adipocytes in a dose-dependent manner. In the in vivo study, supplementation of SM powder (SMP) remarkably attenuated fat accumulation in HFD-induced obese rats. In addition, SMP supplementation improved lipid profiles in the serum and tissues of high-fat induced obese rats. Collectively, these data indicated that SME exhibited antiobesity effects by modulating adipogenesis and lipolysis. Furthermore, SMP could be developed as an obesity-induced metabolic syndrome treatment.
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spelling pubmed-70712102020-03-19 Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats Park, Yong-Hyun Lee, Jae-Joon Son, Hee-Kyoung Kim, Bok-Hee Byun, Jaemin Ha, Jung-Heun Nutrients Article Obesity has recently risen and become a serious health concern in Korea according to the westernized diet and altered lifestyle. Hence, there is a growing interest in the supplementation of phytochemicals to find a safe and effective functional ingredient to treat obesity. Spergularia marina Griseb (SM) has traditionally been used as a natural herb against chronic diseases in Korea. In this study, we investigated the antiobesity effects of SM in vitro and in vivo. SM ethanol extract (SME) inhibited proliferation and differentiation in murine adipocytes and primary porcine pre-adipocytes in a dose-dependent manner. In the in vivo study, supplementation of SM powder (SMP) remarkably attenuated fat accumulation in HFD-induced obese rats. In addition, SMP supplementation improved lipid profiles in the serum and tissues of high-fat induced obese rats. Collectively, these data indicated that SME exhibited antiobesity effects by modulating adipogenesis and lipolysis. Furthermore, SMP could be developed as an obesity-induced metabolic syndrome treatment. MDPI 2020-01-27 /pmc/articles/PMC7071210/ /pubmed/32012750 http://dx.doi.org/10.3390/nu12020336 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Yong-Hyun
Lee, Jae-Joon
Son, Hee-Kyoung
Kim, Bok-Hee
Byun, Jaemin
Ha, Jung-Heun
Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title_full Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title_fullStr Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title_full_unstemmed Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title_short Antiobesity Effects of Extract from Spergularia marina Griseb in Adipocytes and High-Fat Diet-Induced Obese Rats
title_sort antiobesity effects of extract from spergularia marina griseb in adipocytes and high-fat diet-induced obese rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071210/
https://www.ncbi.nlm.nih.gov/pubmed/32012750
http://dx.doi.org/10.3390/nu12020336
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