Cargando…
Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study
Most studies assessing the macronutrient content of human milk are published retrospectively using analyzers that fail to determine sodium content and do not take into account the role of volume in milk composition. We aimed to describe macronutrient content and sodium content in human milk over tim...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071293/ https://www.ncbi.nlm.nih.gov/pubmed/32041195 http://dx.doi.org/10.3390/nu12020421 |
_version_ | 1783506168550785024 |
---|---|
author | Rigourd, Virginie Lopera, Isabel Cata, Florina Benoit, Guy Jacquemet, Benedicte Lapillonne, Alexandre |
author_facet | Rigourd, Virginie Lopera, Isabel Cata, Florina Benoit, Guy Jacquemet, Benedicte Lapillonne, Alexandre |
author_sort | Rigourd, Virginie |
collection | PubMed |
description | Most studies assessing the macronutrient content of human milk are published retrospectively using analyzers that fail to determine sodium content and do not take into account the role of volume in milk composition. We aimed to describe macronutrient content and sodium content in human milk over time, observe any associations between them, and determine the factors associated with the evolution of milk composition. A prospective, longitudinal, monocentric study was undertaken. Contents of protein, fat, and lactose of 102 milk samples from 40 mothers were determined using a human milk analyzer and that of sodium with a flame spectrophotometer. Milk volumes along with clinical data were recorded. Protein content in the fourth quartile of volume was significantly lower than that in the first three, suggesting the existence of a volume threshold for protein content at approximately 445 mL. After multivariate analysis, it was found that maternal age, average volume, and lactation period remained significantly associated with protein content, maternal age remained significantly associated with fat content, and only average volume with sodium content. In consideration of previous findings along with our data, we suggest that extra care should be taken with fortification for feeding preterm infants when the mother’s milk volume is greater than 400–450 mL. |
format | Online Article Text |
id | pubmed-7071293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70712932020-03-19 Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study Rigourd, Virginie Lopera, Isabel Cata, Florina Benoit, Guy Jacquemet, Benedicte Lapillonne, Alexandre Nutrients Article Most studies assessing the macronutrient content of human milk are published retrospectively using analyzers that fail to determine sodium content and do not take into account the role of volume in milk composition. We aimed to describe macronutrient content and sodium content in human milk over time, observe any associations between them, and determine the factors associated with the evolution of milk composition. A prospective, longitudinal, monocentric study was undertaken. Contents of protein, fat, and lactose of 102 milk samples from 40 mothers were determined using a human milk analyzer and that of sodium with a flame spectrophotometer. Milk volumes along with clinical data were recorded. Protein content in the fourth quartile of volume was significantly lower than that in the first three, suggesting the existence of a volume threshold for protein content at approximately 445 mL. After multivariate analysis, it was found that maternal age, average volume, and lactation period remained significantly associated with protein content, maternal age remained significantly associated with fat content, and only average volume with sodium content. In consideration of previous findings along with our data, we suggest that extra care should be taken with fortification for feeding preterm infants when the mother’s milk volume is greater than 400–450 mL. MDPI 2020-02-06 /pmc/articles/PMC7071293/ /pubmed/32041195 http://dx.doi.org/10.3390/nu12020421 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rigourd, Virginie Lopera, Isabel Cata, Florina Benoit, Guy Jacquemet, Benedicte Lapillonne, Alexandre Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title | Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title_full | Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title_fullStr | Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title_full_unstemmed | Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title_short | Role of Daily Milk Volume and Period of Lactation in Nutrient Content of Human Milk: Results from a Prospective Study |
title_sort | role of daily milk volume and period of lactation in nutrient content of human milk: results from a prospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071293/ https://www.ncbi.nlm.nih.gov/pubmed/32041195 http://dx.doi.org/10.3390/nu12020421 |
work_keys_str_mv | AT rigourdvirginie roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy AT loperaisabel roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy AT cataflorina roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy AT benoitguy roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy AT jacquemetbenedicte roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy AT lapillonnealexandre roleofdailymilkvolumeandperiodoflactationinnutrientcontentofhumanmilkresultsfromaprospectivestudy |