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Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study

In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diab...

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Autores principales: Rangaraj, Vittobai Rashika, Siddula, Alankrita, Burgess, Helen J., Pannain, Silvana, Knutson, Kristen L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071301/
https://www.ncbi.nlm.nih.gov/pubmed/32079066
http://dx.doi.org/10.3390/nu12020503
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author Rangaraj, Vittobai Rashika
Siddula, Alankrita
Burgess, Helen J.
Pannain, Silvana
Knutson, Kristen L.
author_facet Rangaraj, Vittobai Rashika
Siddula, Alankrita
Burgess, Helen J.
Pannain, Silvana
Knutson, Kristen L.
author_sort Rangaraj, Vittobai Rashika
collection PubMed
description In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21–50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (n = 44). From the food diary, we calculated the proportions of the total energy and macronutrients consumed in the morning and evening, and the clock time at which 25%, 50% and 75% of total energy was consumed. A greater proportion of energy intake in the morning was significantly associated with higher insulin sensitivity estimated by Matsuda Index (B = 2.8 per 10%; 95%CI: 0.3, 5.2). The time at which 25% of energy was consumed was associated with insulin sensitivity estimated by Matsuda Index (B = −1.6 per hour; 95%CI: −3.0, −0.3) and QUICKI (B = −1.4 per hour, 95%CI: −2.8, −0.1). The timing of carbohydrate consumption demonstrated similar associations. Greater energy intake earlier in the day was associated with higher insulin sensitivity in individuals without diabetes.
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spelling pubmed-70713012020-03-19 Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study Rangaraj, Vittobai Rashika Siddula, Alankrita Burgess, Helen J. Pannain, Silvana Knutson, Kristen L. Nutrients Article In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21–50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (n = 44). From the food diary, we calculated the proportions of the total energy and macronutrients consumed in the morning and evening, and the clock time at which 25%, 50% and 75% of total energy was consumed. A greater proportion of energy intake in the morning was significantly associated with higher insulin sensitivity estimated by Matsuda Index (B = 2.8 per 10%; 95%CI: 0.3, 5.2). The time at which 25% of energy was consumed was associated with insulin sensitivity estimated by Matsuda Index (B = −1.6 per hour; 95%CI: −3.0, −0.3) and QUICKI (B = −1.4 per hour, 95%CI: −2.8, −0.1). The timing of carbohydrate consumption demonstrated similar associations. Greater energy intake earlier in the day was associated with higher insulin sensitivity in individuals without diabetes. MDPI 2020-02-16 /pmc/articles/PMC7071301/ /pubmed/32079066 http://dx.doi.org/10.3390/nu12020503 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rangaraj, Vittobai Rashika
Siddula, Alankrita
Burgess, Helen J.
Pannain, Silvana
Knutson, Kristen L.
Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title_full Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title_fullStr Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title_full_unstemmed Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title_short Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study
title_sort association between timing of energy intake and insulin sensitivity: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071301/
https://www.ncbi.nlm.nih.gov/pubmed/32079066
http://dx.doi.org/10.3390/nu12020503
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