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Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes

Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-...

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Autores principales: Piuri, Gabriele, Basello, Katia, Rossi, Gabriele, Soldavini, Chiara Maria, Duiella, Silvia, Privitera, Giulia, Spadafranca, Angela, Costanzi, Andrea, Tognon, Emiliana, Cappelletti, Mattia, Corsetto, Paola Antonia, Rizzo, Angela Maria, Speciani, Attilio Francesco, Ferrazzi, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071306/
https://www.ncbi.nlm.nih.gov/pubmed/32074941
http://dx.doi.org/10.3390/nu12020479
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author Piuri, Gabriele
Basello, Katia
Rossi, Gabriele
Soldavini, Chiara Maria
Duiella, Silvia
Privitera, Giulia
Spadafranca, Angela
Costanzi, Andrea
Tognon, Emiliana
Cappelletti, Mattia
Corsetto, Paola Antonia
Rizzo, Angela Maria
Speciani, Attilio Francesco
Ferrazzi, Enrico
author_facet Piuri, Gabriele
Basello, Katia
Rossi, Gabriele
Soldavini, Chiara Maria
Duiella, Silvia
Privitera, Giulia
Spadafranca, Angela
Costanzi, Andrea
Tognon, Emiliana
Cappelletti, Mattia
Corsetto, Paola Antonia
Rizzo, Angela Maria
Speciani, Attilio Francesco
Ferrazzi, Enrico
author_sort Piuri, Gabriele
collection PubMed
description Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM. Methods: We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism. Results: In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4–47.5) ng/mL to 40.1 (30.5–80.5) ng/mL (p < 0.001). Their TNF-α levels increased from 3.0 (2.8–3.5) pg/mL to 3.4 (3.1–5.8) pg/mL (p < 0.001). The levels of methylglyoxal were significantly higher in the women with GDM (p < 0.001), both at diagnosis and after 12 weeks (0.64 (0.46–0.90) μg/mL; 0.71 (0.47–0.93) μg/mL, respectively) compared to general population (0.25 (0.19–0.28) μg/mL). Levels of glycated albumin were significantly higher in women with GDM (p < 0.001) only after 12 weeks from diagnosis (1.51 (0.88–2.03) nmol/mL) compared to general population (0.95 (0.63–1.4) nmol/mL). Conclusion: These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results.
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spelling pubmed-70713062020-03-19 Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes Piuri, Gabriele Basello, Katia Rossi, Gabriele Soldavini, Chiara Maria Duiella, Silvia Privitera, Giulia Spadafranca, Angela Costanzi, Andrea Tognon, Emiliana Cappelletti, Mattia Corsetto, Paola Antonia Rizzo, Angela Maria Speciani, Attilio Francesco Ferrazzi, Enrico Nutrients Article Background: In gestational diabetes mellitus (GDM), pancreatic β-cell breakdown can result from a proinflammatory imbalance created by a sustained level of cytokines. In this study, we investigated the role of specific cytokines, such as B-cell activating factor (BAFF), tumor necrosis factor α (TNF-α), and platelet-activating factor (PAF), together with methylglyoxal (MGO) and glycated albumin (GA) in pregnant women affected by GDM. Methods: We enrolled 30 women whose inflammation and metabolic markers were measured at recruitment and after 12 weeks of strict dietetic therapy. We compared these data to the data obtained from 53 randomly selected healthy nonpregnant subjects without diabetes, hyperglycemia, or any condition that can affect glycemic metabolism. Results: In pregnant women affected by GDM, PAF levels increased from 26.3 (17.4–47.5) ng/mL to 40.1 (30.5–80.5) ng/mL (p < 0.001). Their TNF-α levels increased from 3.0 (2.8–3.5) pg/mL to 3.4 (3.1–5.8) pg/mL (p < 0.001). The levels of methylglyoxal were significantly higher in the women with GDM (p < 0.001), both at diagnosis and after 12 weeks (0.64 (0.46–0.90) μg/mL; 0.71 (0.47–0.93) μg/mL, respectively) compared to general population (0.25 (0.19–0.28) μg/mL). Levels of glycated albumin were significantly higher in women with GDM (p < 0.001) only after 12 weeks from diagnosis (1.51 (0.88–2.03) nmol/mL) compared to general population (0.95 (0.63–1.4) nmol/mL). Conclusion: These findings support the involvement of new inflammatory and metabolic biomarkers in the mechanisms related to GDM complications and prompt deeper exploration into the vicious cycle connecting inflammation, oxidative stress, and metabolic results. MDPI 2020-02-14 /pmc/articles/PMC7071306/ /pubmed/32074941 http://dx.doi.org/10.3390/nu12020479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piuri, Gabriele
Basello, Katia
Rossi, Gabriele
Soldavini, Chiara Maria
Duiella, Silvia
Privitera, Giulia
Spadafranca, Angela
Costanzi, Andrea
Tognon, Emiliana
Cappelletti, Mattia
Corsetto, Paola Antonia
Rizzo, Angela Maria
Speciani, Attilio Francesco
Ferrazzi, Enrico
Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title_full Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title_fullStr Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title_full_unstemmed Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title_short Methylglyoxal, Glycated Albumin, PAF, and TNF-α: Possible Inflammatory and Metabolic Biomarkers for Management of Gestational Diabetes
title_sort methylglyoxal, glycated albumin, paf, and tnf-α: possible inflammatory and metabolic biomarkers for management of gestational diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071306/
https://www.ncbi.nlm.nih.gov/pubmed/32074941
http://dx.doi.org/10.3390/nu12020479
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