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Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study

Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total l...

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Autores principales: Sotomayor, Camilo G., Minović, Isidor, Eggersdorfer, Manfred L., Riphagen, Ineke J., de Borst, Martin H., Dekker, Louise H., Nolte, Ilja M., Frank, Jan, van Zon, Sander K.R., Reijneveld, Sijmen A., van der Molen, Jan C., Vos, Michel J., Kootstra-Ros, Jenny E., Rodrigo, Ramón, Kema, Ido P., Navis, Gerjan J., Bakker, Stephan J.L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071362/
https://www.ncbi.nlm.nih.gov/pubmed/32102191
http://dx.doi.org/10.3390/nu12020580
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author Sotomayor, Camilo G.
Minović, Isidor
Eggersdorfer, Manfred L.
Riphagen, Ineke J.
de Borst, Martin H.
Dekker, Louise H.
Nolte, Ilja M.
Frank, Jan
van Zon, Sander K.R.
Reijneveld, Sijmen A.
van der Molen, Jan C.
Vos, Michel J.
Kootstra-Ros, Jenny E.
Rodrigo, Ramón
Kema, Ido P.
Navis, Gerjan J.
Bakker, Stephan J.L.
author_facet Sotomayor, Camilo G.
Minović, Isidor
Eggersdorfer, Manfred L.
Riphagen, Ineke J.
de Borst, Martin H.
Dekker, Louise H.
Nolte, Ilja M.
Frank, Jan
van Zon, Sander K.R.
Reijneveld, Sijmen A.
van der Molen, Jan C.
Vos, Michel J.
Kootstra-Ros, Jenny E.
Rodrigo, Ramón
Kema, Ido P.
Navis, Gerjan J.
Bakker, Stephan J.L.
author_sort Sotomayor, Camilo G.
collection PubMed
description Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied.
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spelling pubmed-70713622020-03-19 Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study Sotomayor, Camilo G. Minović, Isidor Eggersdorfer, Manfred L. Riphagen, Ineke J. de Borst, Martin H. Dekker, Louise H. Nolte, Ilja M. Frank, Jan van Zon, Sander K.R. Reijneveld, Sijmen A. van der Molen, Jan C. Vos, Michel J. Kootstra-Ros, Jenny E. Rodrigo, Ramón Kema, Ido P. Navis, Gerjan J. Bakker, Stephan J.L. Nutrients Article Whether the affinity of serum vitamin E with total lipids hampers the appropriate assessment of its association with age-related risk factors has not been investigated in epidemiological studies. We aimed to compare linear regression-derived coefficients of the association of non-indexed and total lipids-indexed vitamin E isoforms with clinical and laboratory characteristics pertaining to the lipid, metabolic syndrome, and one-carbon metabolism biological domains. We studied 1429 elderly subjects (non-vitamin supplement users, 60–75 years old, with low and high socioeconomic status) from the population-based LifeLines Cohort and Biobank Study. We found that the associations of tocopherol isoforms with lipids were inverted in total lipids-indexed analyses, which may be indicative of overcorrection. Irrespective of the methods of standardization, we consistently found positive associations of α-tocopherol with vitamins of the one-carbon metabolism pathway and inverse associations with characteristics related to glucose metabolism. The associations of γ-tocopherol were often opposite to those of α-tocopherol. These data suggest that tocopherol isoforms and one-carbon metabolism are related, with beneficial and adverse associations for α-tocopherol and γ-tocopherol, respectively. Whether tocopherol isoforms, or their interplay, truly affect the one-carbon metabolism pathway remains to be further studied. MDPI 2020-02-23 /pmc/articles/PMC7071362/ /pubmed/32102191 http://dx.doi.org/10.3390/nu12020580 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sotomayor, Camilo G.
Minović, Isidor
Eggersdorfer, Manfred L.
Riphagen, Ineke J.
de Borst, Martin H.
Dekker, Louise H.
Nolte, Ilja M.
Frank, Jan
van Zon, Sander K.R.
Reijneveld, Sijmen A.
van der Molen, Jan C.
Vos, Michel J.
Kootstra-Ros, Jenny E.
Rodrigo, Ramón
Kema, Ido P.
Navis, Gerjan J.
Bakker, Stephan J.L.
Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title_full Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title_fullStr Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title_full_unstemmed Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title_short Duality of Tocopherol Isoforms and Novel Associations with Vitamins Involved in One-Carbon Metabolism: Results from an Elderly Sample of the LifeLines Cohort Study
title_sort duality of tocopherol isoforms and novel associations with vitamins involved in one-carbon metabolism: results from an elderly sample of the lifelines cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071362/
https://www.ncbi.nlm.nih.gov/pubmed/32102191
http://dx.doi.org/10.3390/nu12020580
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