Cargando…

Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases

Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Feiyun, Zhou, Zhiru, Zhou, H. Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071405/
https://www.ncbi.nlm.nih.gov/pubmed/32069788
http://dx.doi.org/10.3390/s20040996
_version_ 1783506193971412992
author Cui, Feiyun
Zhou, Zhiru
Zhou, H. Susan
author_facet Cui, Feiyun
Zhou, Zhiru
Zhou, H. Susan
author_sort Cui, Feiyun
collection PubMed
description Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed.
format Online
Article
Text
id pubmed-7071405
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70714052020-03-19 Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases Cui, Feiyun Zhou, Zhiru Zhou, H. Susan Sensors (Basel) Review Owing to their merits of simple, fast, sensitive, and low cost, electrochemical biosensors have been widely used for the diagnosis of infectious diseases. As a critical element, the receptor determines the selectivity, stability, and accuracy of the electrochemical biosensors. Molecularly imprinted polymers (MIPs) and surface imprinted polymers (SIPs) have great potential to be robust artificial receptors. Therefore, extensive studies have been reported to develop MIPs/SIPs for the detection of infectious diseases with high selectivity and reliability. In this review, we discuss mechanisms of recognition events between imprinted polymers with different biomarkers, such as signaling molecules, microbial toxins, viruses, and bacterial and fungal cells. Then, various preparation methods of MIPs/SIPs for electrochemical biosensors are summarized. Especially, the methods of electropolymerization and micro-contact imprinting are emphasized. Furthermore, applications of MIPs/SIPs based electrochemical biosensors for infectious disease detection are highlighted. At last, challenges and perspectives are discussed. MDPI 2020-02-13 /pmc/articles/PMC7071405/ /pubmed/32069788 http://dx.doi.org/10.3390/s20040996 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cui, Feiyun
Zhou, Zhiru
Zhou, H. Susan
Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title_full Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title_fullStr Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title_full_unstemmed Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title_short Molecularly Imprinted Polymers and Surface Imprinted Polymers Based Electrochemical Biosensor for Infectious Diseases
title_sort molecularly imprinted polymers and surface imprinted polymers based electrochemical biosensor for infectious diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071405/
https://www.ncbi.nlm.nih.gov/pubmed/32069788
http://dx.doi.org/10.3390/s20040996
work_keys_str_mv AT cuifeiyun molecularlyimprintedpolymersandsurfaceimprintedpolymersbasedelectrochemicalbiosensorforinfectiousdiseases
AT zhouzhiru molecularlyimprintedpolymersandsurfaceimprintedpolymersbasedelectrochemicalbiosensorforinfectiousdiseases
AT zhouhsusan molecularlyimprintedpolymersandsurfaceimprintedpolymersbasedelectrochemicalbiosensorforinfectiousdiseases