Cargando…
The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing ent...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071410/ https://www.ncbi.nlm.nih.gov/pubmed/32093194 http://dx.doi.org/10.3390/nu12020546 |
_version_ | 1783506195165741056 |
---|---|
author | Burge, Kathryn Bergner, Erynn Gunasekaran, Aarthi Eckert, Jeffrey Chaaban, Hala |
author_facet | Burge, Kathryn Bergner, Erynn Gunasekaran, Aarthi Eckert, Jeffrey Chaaban, Hala |
author_sort | Burge, Kathryn |
collection | PubMed |
description | Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans. |
format | Online Article Text |
id | pubmed-7071410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70714102020-03-19 The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review Burge, Kathryn Bergner, Erynn Gunasekaran, Aarthi Eckert, Jeffrey Chaaban, Hala Nutrients Review Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans. MDPI 2020-02-20 /pmc/articles/PMC7071410/ /pubmed/32093194 http://dx.doi.org/10.3390/nu12020546 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Burge, Kathryn Bergner, Erynn Gunasekaran, Aarthi Eckert, Jeffrey Chaaban, Hala The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title | The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title_full | The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title_fullStr | The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title_full_unstemmed | The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title_short | The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review |
title_sort | role of glycosaminoglycans in protection from neonatal necrotizing enterocolitis: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071410/ https://www.ncbi.nlm.nih.gov/pubmed/32093194 http://dx.doi.org/10.3390/nu12020546 |
work_keys_str_mv | AT burgekathryn theroleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT bergnererynn theroleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT gunasekaranaarthi theroleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT eckertjeffrey theroleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT chaabanhala theroleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT burgekathryn roleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT bergnererynn roleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT gunasekaranaarthi roleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT eckertjeffrey roleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview AT chaabanhala roleofglycosaminoglycansinprotectionfromneonatalnecrotizingenterocolitisanarrativereview |