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The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review

Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing ent...

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Autores principales: Burge, Kathryn, Bergner, Erynn, Gunasekaran, Aarthi, Eckert, Jeffrey, Chaaban, Hala
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071410/
https://www.ncbi.nlm.nih.gov/pubmed/32093194
http://dx.doi.org/10.3390/nu12020546
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author Burge, Kathryn
Bergner, Erynn
Gunasekaran, Aarthi
Eckert, Jeffrey
Chaaban, Hala
author_facet Burge, Kathryn
Bergner, Erynn
Gunasekaran, Aarthi
Eckert, Jeffrey
Chaaban, Hala
author_sort Burge, Kathryn
collection PubMed
description Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans.
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spelling pubmed-70714102020-03-19 The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review Burge, Kathryn Bergner, Erynn Gunasekaran, Aarthi Eckert, Jeffrey Chaaban, Hala Nutrients Review Necrotizing enterocolitis, a potentially fatal intestinal inflammatory disorder affecting primarily premature infants, is a significant cause of morbidity and mortality in neonates. While the etiology of the disease is, as yet, unknown, a number of risk factors for the development of necrotizing enterocolitis have been identified. One such risk factor, formula feeding, has been shown to contribute to both increased incidence and severity of the disease. The protective influences afforded by breastfeeding are likely attributable to the unique composition of human milk, an extremely potent, biologically active fluid. This review brings together knowledge on the pathogenesis of necrotizing enterocolitis and current thinking on the instrumental role of one of the more prominent classes of bioactive components in human breast milk, glycosaminoglycans. MDPI 2020-02-20 /pmc/articles/PMC7071410/ /pubmed/32093194 http://dx.doi.org/10.3390/nu12020546 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Burge, Kathryn
Bergner, Erynn
Gunasekaran, Aarthi
Eckert, Jeffrey
Chaaban, Hala
The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title_full The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title_fullStr The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title_full_unstemmed The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title_short The Role of Glycosaminoglycans in Protection from Neonatal Necrotizing Enterocolitis: A Narrative Review
title_sort role of glycosaminoglycans in protection from neonatal necrotizing enterocolitis: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071410/
https://www.ncbi.nlm.nih.gov/pubmed/32093194
http://dx.doi.org/10.3390/nu12020546
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