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Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives

Despite the obvious sex differences in many of the most common neuropsychiatric and neurodegenerative disorders, males and females are still often treated the same from a clinical perspective. Why is that? The simple answer is that there is still too little known about this very complex matter. Sex...

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Detalles Bibliográficos
Autor principal: Nalvarte, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071507/
https://www.ncbi.nlm.nih.gov/pubmed/32075025
http://dx.doi.org/10.3390/brainsci10020103
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author Nalvarte, Ivan
author_facet Nalvarte, Ivan
author_sort Nalvarte, Ivan
collection PubMed
description Despite the obvious sex differences in many of the most common neuropsychiatric and neurodegenerative disorders, males and females are still often treated the same from a clinical perspective. Why is that? The simple answer is that there is still too little known about this very complex matter. Sex hormone signaling, genetic sex, sex-biased comorbidities, and social gender perceptions all interact, making discrimination between the impacts of each of these factors hard to evaluate. Adding to the complexity is that important species differences must be taken into account when interpreting data from animal models. Clearly, to overcome this, larger efforts are needed that incorporate epidemiological, experimental, and clinical data to provide a solid scientific base for more personalized and informed clinical decisions that will benefit both men and women suffering from neurological disorders.
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spelling pubmed-70715072020-03-19 Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives Nalvarte, Ivan Brain Sci Editorial Despite the obvious sex differences in many of the most common neuropsychiatric and neurodegenerative disorders, males and females are still often treated the same from a clinical perspective. Why is that? The simple answer is that there is still too little known about this very complex matter. Sex hormone signaling, genetic sex, sex-biased comorbidities, and social gender perceptions all interact, making discrimination between the impacts of each of these factors hard to evaluate. Adding to the complexity is that important species differences must be taken into account when interpreting data from animal models. Clearly, to overcome this, larger efforts are needed that incorporate epidemiological, experimental, and clinical data to provide a solid scientific base for more personalized and informed clinical decisions that will benefit both men and women suffering from neurological disorders. MDPI 2020-02-14 /pmc/articles/PMC7071507/ /pubmed/32075025 http://dx.doi.org/10.3390/brainsci10020103 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Nalvarte, Ivan
Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title_full Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title_fullStr Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title_full_unstemmed Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title_short Sex Stratified Treatment of Neurological Disorders: Challenges and Perspectives
title_sort sex stratified treatment of neurological disorders: challenges and perspectives
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071507/
https://www.ncbi.nlm.nih.gov/pubmed/32075025
http://dx.doi.org/10.3390/brainsci10020103
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