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Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity

Objective: Oxidation is involved in secondary brain injury after traumatic brain injury (TBI). Increased concentrations of total antioxidant capacity (TAC) in blood at the time of admission for TBI have been found in non-surviving patients. The main objective of this study was to determine the role...

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Autores principales: Lorente, Leonardo, Martín, María M., Pérez-Cejas, Antonia, González-Rivero, Agustín F., Abreu-González, Pedro, Ramos, Luis, Argueso, Mónica, Solé-Violán, Jordi, Cáceres, Juan J., Jiménez, Alejandro, García-Marín, Victor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071510/
https://www.ncbi.nlm.nih.gov/pubmed/32085496
http://dx.doi.org/10.3390/brainsci10020110
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author Lorente, Leonardo
Martín, María M.
Pérez-Cejas, Antonia
González-Rivero, Agustín F.
Abreu-González, Pedro
Ramos, Luis
Argueso, Mónica
Solé-Violán, Jordi
Cáceres, Juan J.
Jiménez, Alejandro
García-Marín, Victor
author_facet Lorente, Leonardo
Martín, María M.
Pérez-Cejas, Antonia
González-Rivero, Agustín F.
Abreu-González, Pedro
Ramos, Luis
Argueso, Mónica
Solé-Violán, Jordi
Cáceres, Juan J.
Jiménez, Alejandro
García-Marín, Victor
author_sort Lorente, Leonardo
collection PubMed
description Objective: Oxidation is involved in secondary brain injury after traumatic brain injury (TBI). Increased concentrations of total antioxidant capacity (TAC) in blood at the time of admission for TBI have been found in non-surviving patients. The main objective of this study was to determine the role of serum TAC levels at any time during the first week of TBI for the prediction of early mortality. Methods: Isolated (<10 points in non-cranial aspects of Injury Severity Score) and severe (<9 points in Glasgow Coma Scale) TBI patients were included. Serum TAC concentrations at days 1, 4, and 8 of TBI were determined. The end-point study was 30-day mortality. Results: Higher serum TAC levels at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p = 0.002) of TBI were found in non-surviving (n = 34) than in surviving patients (n = 90). The area under curve (95% Confidence Interval) for prediction of 30-day mortality by serum TAC concentrations at days 1, 4, and 8 of TBI were 0.79 (0.71–0.86; p < 0.001), 0.87 (0.79–0.93; p < 0.001), and 0.76 (0.67–0.84; p = 0.006) respectively. Conclusions: The novelty of our study was the ability to predict 30-day mortality by serum TAC concentrations at any time during the first week of TBI.
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spelling pubmed-70715102020-03-19 Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity Lorente, Leonardo Martín, María M. Pérez-Cejas, Antonia González-Rivero, Agustín F. Abreu-González, Pedro Ramos, Luis Argueso, Mónica Solé-Violán, Jordi Cáceres, Juan J. Jiménez, Alejandro García-Marín, Victor Brain Sci Article Objective: Oxidation is involved in secondary brain injury after traumatic brain injury (TBI). Increased concentrations of total antioxidant capacity (TAC) in blood at the time of admission for TBI have been found in non-surviving patients. The main objective of this study was to determine the role of serum TAC levels at any time during the first week of TBI for the prediction of early mortality. Methods: Isolated (<10 points in non-cranial aspects of Injury Severity Score) and severe (<9 points in Glasgow Coma Scale) TBI patients were included. Serum TAC concentrations at days 1, 4, and 8 of TBI were determined. The end-point study was 30-day mortality. Results: Higher serum TAC levels at days 1 (p < 0.001), 4 (p < 0.001), and 8 (p = 0.002) of TBI were found in non-surviving (n = 34) than in surviving patients (n = 90). The area under curve (95% Confidence Interval) for prediction of 30-day mortality by serum TAC concentrations at days 1, 4, and 8 of TBI were 0.79 (0.71–0.86; p < 0.001), 0.87 (0.79–0.93; p < 0.001), and 0.76 (0.67–0.84; p = 0.006) respectively. Conclusions: The novelty of our study was the ability to predict 30-day mortality by serum TAC concentrations at any time during the first week of TBI. MDPI 2020-02-18 /pmc/articles/PMC7071510/ /pubmed/32085496 http://dx.doi.org/10.3390/brainsci10020110 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lorente, Leonardo
Martín, María M.
Pérez-Cejas, Antonia
González-Rivero, Agustín F.
Abreu-González, Pedro
Ramos, Luis
Argueso, Mónica
Solé-Violán, Jordi
Cáceres, Juan J.
Jiménez, Alejandro
García-Marín, Victor
Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title_full Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title_fullStr Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title_full_unstemmed Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title_short Traumatic Brain Injury Patients Mortality and Serum Total Antioxidant Capacity
title_sort traumatic brain injury patients mortality and serum total antioxidant capacity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071510/
https://www.ncbi.nlm.nih.gov/pubmed/32085496
http://dx.doi.org/10.3390/brainsci10020110
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