Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics

BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variati...

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Detalles Bibliográficos
Autores principales: Hodonsky, Chani J., Baldassari, Antoine R., Bien, Stephanie A., Raffield, Laura M., Highland, Heather M., Sitlani, Colleen M., Wojcik, Genevieve L., Tao, Ran, Graff, Marielisa, Tang, Weihong, Thyagarajan, Bharat, Buyske, Steve, Fornage, Myriam, Hindorff, Lucia A., Li, Yun, Lin, Danyu, Reiner, Alex P., North, Kari E., Loos, Ruth J. F., Kooperberg, Charles, Avery, Christy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071748/
https://www.ncbi.nlm.nih.gov/pubmed/32171239
http://dx.doi.org/10.1186/s12864-020-6626-9

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