Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model

BACKGROUND: Proving that specific genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identification of suitable targets for drug development. This is especially evident in the absence of a robust inducible expression system or f...

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Detalles Bibliográficos
Autores principales: Paape, Daniel, Prendergast, Catriona T., Price, Helen P., Doehl, Johannes S. P., Smith, Deborah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071782/
https://www.ncbi.nlm.nih.gov/pubmed/32171322
http://dx.doi.org/10.1186/s13071-020-3999-1

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