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Major miRNA Involved in Insulin Secretion and Production in Beta-Cells

Insulin is implicated as a leading factor in glucose homeostasis and an important theme in diabetes mellitus (DM). Numerous proteins are involved in insulin signaling pathway and their dysregulation contributes to DM. microRNAs (miRNAs) as single-strand molecules have a critical effect on gene expre...

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Autores principales: Aghaei, Mohsen, Khodadadian, Ali, Elham, Karimi-Nazari, Nazari, Majid, Babakhanzadeh, Emad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071856/
https://www.ncbi.nlm.nih.gov/pubmed/32210605
http://dx.doi.org/10.2147/IJGM.S249011
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author Aghaei, Mohsen
Khodadadian, Ali
Elham, Karimi-Nazari
Nazari, Majid
Babakhanzadeh, Emad
author_facet Aghaei, Mohsen
Khodadadian, Ali
Elham, Karimi-Nazari
Nazari, Majid
Babakhanzadeh, Emad
author_sort Aghaei, Mohsen
collection PubMed
description Insulin is implicated as a leading factor in glucose homeostasis and an important theme in diabetes mellitus (DM). Numerous proteins are involved in insulin signaling pathway and their dysregulation contributes to DM. microRNAs (miRNAs) as single-strand molecules have a critical effect on gene expression at post-transcriptional levels. Intensive investigation done by DM researchers disclosed that miRNAs have a significant role in insulin secretion by direct targeting numerous proteins engaged in insulin signaling pathway; so, their dysregulation contributes to DM. In this review, we presented some major miRNAs engaged in the insulin production and secretion.
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spelling pubmed-70718562020-03-24 Major miRNA Involved in Insulin Secretion and Production in Beta-Cells Aghaei, Mohsen Khodadadian, Ali Elham, Karimi-Nazari Nazari, Majid Babakhanzadeh, Emad Int J Gen Med Review Insulin is implicated as a leading factor in glucose homeostasis and an important theme in diabetes mellitus (DM). Numerous proteins are involved in insulin signaling pathway and their dysregulation contributes to DM. microRNAs (miRNAs) as single-strand molecules have a critical effect on gene expression at post-transcriptional levels. Intensive investigation done by DM researchers disclosed that miRNAs have a significant role in insulin secretion by direct targeting numerous proteins engaged in insulin signaling pathway; so, their dysregulation contributes to DM. In this review, we presented some major miRNAs engaged in the insulin production and secretion. Dove 2020-03-10 /pmc/articles/PMC7071856/ /pubmed/32210605 http://dx.doi.org/10.2147/IJGM.S249011 Text en © 2020 Aghaei et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Aghaei, Mohsen
Khodadadian, Ali
Elham, Karimi-Nazari
Nazari, Majid
Babakhanzadeh, Emad
Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title_full Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title_fullStr Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title_full_unstemmed Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title_short Major miRNA Involved in Insulin Secretion and Production in Beta-Cells
title_sort major mirna involved in insulin secretion and production in beta-cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071856/
https://www.ncbi.nlm.nih.gov/pubmed/32210605
http://dx.doi.org/10.2147/IJGM.S249011
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