Cargando…

Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis

OBJECTIVE: Recent studies have shown that tumor-associated macrophages (TAMs) play an important role in cancer invasion and metastasis. Our previous studies have reported that TAMs promote the invasion and metastasis of gastric cancer (GC) cells through the Kindlin-2 pathway. However, the mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhu, Yang, Yang, Cui, Yancheng, Wang, Chao, Lai, Zhiyong, Li, Yansen, Zhang, Wei, Mustonen, Harri, Puolakkainen, Pauli, Ye, Yingjiang, Jiang, Kewei, Shen, Zhanlong, Wang, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072013/ https://www.ncbi.nlm.nih.gov/pubmed/32194307 http://dx.doi.org/10.21147/j.issn.1000-9604.2020.01.09

Ejemplares similares

A novel long non-coding RNA lnc-GNAT1-1 is low expressed in colorectal cancer and acts as a tumor suppressor through regulating RKIP-NF-κB-Snail circuit
por: Ye, Chunxiang, et al.
Publicado: (2016)

Corrigendum to Tumor-associated macrophages regulate gastric cancer cell invasion and metastasis through TGFβ2/NF-κB/Kindlin-2 axis
Publicado: (2022)

MicroRNA-4284 promotes gastric cancer tumorigenicity by targeting ten-eleven translocation 1
por: Li, Yansen, et al.
Publicado: (2018)

Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
por: Zhan, Jun, et al.
Publicado: (2012)

Increasing the Inflammatory Competence of Macrophages with IL-6 or with Combination of IL-4 and LPS Restrains the Invasiveness of Pancreatic Cancer Cells
por: Salmiheimo, Aino N.E., et al.
Publicado: (2016)

Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
por: Gao, Huanqing, et al.
Publicado: (2023)

Kindlin-2 controls TGF-β signalling and Sox9 expression to regulate chondrogenesis
por: Wu, Chuanyue, et al.
Publicado: (2015)

Characteristics of alpha-fetoprotein-positive gastric cancer revealed by analysis of cancer databases and transcriptome sequencing data
por: Li, Yansen, et al.
Publicado: (2023)

Blood Leukocyte Signaling Pathways as Predictors of Severity of Acute Pancreatitis
por: Turunen, Antti, et al.
Publicado: (2021)

hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway
por: Zhang, Wei, et al.
Publicado: (2022)

Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2
por: Mia, Md Saimon, et al.
Publicado: (2021)

Of Kindlins and Cancer
por: Plow, Edward F., et al.
Publicado: (2016)

PPy@Fe(3)O(4) nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis
por: Yu, Zhilong, et al.
Publicado: (2022)

Corrigendum: PPy@Fe(3)O(4) nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis
por: Yu, Zhilong, et al.
Publicado: (2023)

Kindlin-2 deficiency induces fatal intestinal obstruction in mice
por: He, Xiaokun, et al.
Publicado: (2020)

Young adults with colon cancer: clinical features and surgical outcomes
por: Wang, Chao, et al.
Publicado: (2023)

GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
por: Rohena, Cristina, et al.
Publicado: (2020)

Corrigendum: Yu et al. PPy@Fe(3)O(4) nanoparticles inhibit the proliferation and metastasis of CRC via suppressing the NF-κB signaling pathway and promoting ferroptosis
por: Yu, Zhilong, et al.
Publicado: (2022)

The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer
por: Sossey-Alaoui, Khalid, et al.
Publicado: (2019)

Circulating nucleosomes as predictive markers of severe acute pancreatitis
por: Penttilä, Anne K., et al.
Publicado: (2016)

Systemic Inflammatory Response and Elevated Tumour Markers Predict Worse Survival in Resectable Pancreatic Ductal Adenocarcinoma
por: Salmiheimo, Aino, et al.
Publicado: (2016)

Focal adhesion molecule Kindlin-1 mediates activation of TGF-β signaling by interacting with TGF-βRI, SARA and Smad3 in colorectal cancer cells
por: Kong, Jinfeng, et al.
Publicado: (2016)

Knockdown of the KINDLIN-2 Gene and Reduced Expression of Kindlin-2 Affects Vascular Permeability in Angiogenesis in a Mouse Model of Wound Healing
por: Ying, Jianghui, et al.
Publicado: (2018)

Functional characterization of human Kindlin-2 core promoter identifies a key role of SP1 in Kindlin-2 transcriptional regulation
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

IDH1 K224 acetylation promotes colorectal cancer via miR-9-5p/NHE1 axis-mediated regulation of acidic microenvironment
por: Wang, Bo, et al.
Publicado: (2023)

Kindlin-2 links mechano-environment to proline synthesis and tumor growth
por: Guo, Ling, et al.
Publicado: (2019)

Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
por: Cao, Huiling, et al.
Publicado: (2020)

Lnc-HSD17B11-1:1 Functions as a Competing Endogenous RNA to Promote Colorectal Cancer Progression by Sponging miR-338-3p to Upregulate MACC1
por: Zhang, Wei, et al.
Publicado: (2020)

Kindlin-2 is required for myocyte elongation and is essential for myogenesis
por: Dowling, James J, et al.
Publicado: (2008)

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts
por: Godbout, Elena, et al.
Publicado: (2020)

Use of Genome-Wide Association Studies for Cancer Research and Drug Repositioning
por: Zhang, Jizhun, et al.
Publicado: (2015)

Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis
por: Li, Zhongwen, et al.
Publicado: (2017)

Prognostic implications of Kindlin proteins in human osteosarcoma
por: Ning, Kai, et al.
Publicado: (2017)

Pancreatic Cancer Organoids in the Field of Precision Medicine: A Review of Literature and Experience on Drug Sensitivity Testing with Multiple Readouts and Synergy Scoring
por: Mäkinen, Lotta, et al.
Publicado: (2022)

Kindlin-2 mediates mechanotransduction in bone by regulating expression of Sclerostin in osteocytes
por: Qin, Lei, et al.
Publicado: (2021)

Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice
por: Chi, Xiaochun, et al.
Publicado: (2021)

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis: Nrf2/HMGB1 affects osteoarthritis
por: Li, Wenzhao, et al.
Publicado: (2023)

Molecular Characterization and Clinical Relevance of RNA Binding Proteins in Colorectal Cancer
por: Zhang, Zhen, et al.
Publicado: (2020)

Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous epithelial stem cell proliferation
por: Rognoni, Emanuel, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rer5guvq08at1m6nu3j1e2gh05