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Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?

Thyroid cancer (TC) is the most common cancer of the endocrine system. Most new diagnoses are of low-grade papillary thyroid cancer (PTC), suggesting that PTC may be over-diagnosed. However, the incidence of advanced-stage PTC has increased in recent years. It is therefore very important to identify...

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Autores principales: Hińcza, Kinga, Kowalik, Artur, Pałyga, Iwona, Walczyk, Agnieszka, Gąsior-Perczak, Danuta, Mikina, Estera, Trybek, Tomasz, Szymonek, Monika, Gadawska-Juszczyk, Klaudia, Zajkowska, Klaudia, Suligowska, Agnieszka, Kuchareczko, Artur, Krawczyk, Karol, Kopczyński, Janusz, Chrapek, Magdalena, Góźdź, Stanisław, Kowalska, Aldona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072153/
https://www.ncbi.nlm.nih.gov/pubmed/32059462
http://dx.doi.org/10.3390/cancers12020423
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author Hińcza, Kinga
Kowalik, Artur
Pałyga, Iwona
Walczyk, Agnieszka
Gąsior-Perczak, Danuta
Mikina, Estera
Trybek, Tomasz
Szymonek, Monika
Gadawska-Juszczyk, Klaudia
Zajkowska, Klaudia
Suligowska, Agnieszka
Kuchareczko, Artur
Krawczyk, Karol
Kopczyński, Janusz
Chrapek, Magdalena
Góźdź, Stanisław
Kowalska, Aldona
author_facet Hińcza, Kinga
Kowalik, Artur
Pałyga, Iwona
Walczyk, Agnieszka
Gąsior-Perczak, Danuta
Mikina, Estera
Trybek, Tomasz
Szymonek, Monika
Gadawska-Juszczyk, Klaudia
Zajkowska, Klaudia
Suligowska, Agnieszka
Kuchareczko, Artur
Krawczyk, Karol
Kopczyński, Janusz
Chrapek, Magdalena
Góźdź, Stanisław
Kowalska, Aldona
author_sort Hińcza, Kinga
collection PubMed
description Thyroid cancer (TC) is the most common cancer of the endocrine system. Most new diagnoses are of low-grade papillary thyroid cancer (PTC), suggesting that PTC may be over-diagnosed. However, the incidence of advanced-stage PTC has increased in recent years. It is therefore very important to identify prognostic factors for advanced PTC. Somatic mutation of the BRAF gene at V600E, or the coexistence of the BRAF V600E mutation and mutations in the TERT promoter are associated with more aggressive disease. It would also be valuable to identify genetic risk factors affecting PTC prognosis. We therefore evaluated the impact of the rs966423 polymorphism in the DIRC3 gene, including its relationship with unfavorable histopathological and clinical features and mortality, in differentiated thyroid cancer (DTC). The study included 1466 patients diagnosed with DTC from one center. There was no significant association between the DIRC3 genotype at rs966423 (CC, CT, or TT) and any histopathological or clinic factor examined, including initial response to therapy, response at follow-up, or overall mortality, in DTC patients.
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spelling pubmed-70721532020-03-19 Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer? Hińcza, Kinga Kowalik, Artur Pałyga, Iwona Walczyk, Agnieszka Gąsior-Perczak, Danuta Mikina, Estera Trybek, Tomasz Szymonek, Monika Gadawska-Juszczyk, Klaudia Zajkowska, Klaudia Suligowska, Agnieszka Kuchareczko, Artur Krawczyk, Karol Kopczyński, Janusz Chrapek, Magdalena Góźdź, Stanisław Kowalska, Aldona Cancers (Basel) Article Thyroid cancer (TC) is the most common cancer of the endocrine system. Most new diagnoses are of low-grade papillary thyroid cancer (PTC), suggesting that PTC may be over-diagnosed. However, the incidence of advanced-stage PTC has increased in recent years. It is therefore very important to identify prognostic factors for advanced PTC. Somatic mutation of the BRAF gene at V600E, or the coexistence of the BRAF V600E mutation and mutations in the TERT promoter are associated with more aggressive disease. It would also be valuable to identify genetic risk factors affecting PTC prognosis. We therefore evaluated the impact of the rs966423 polymorphism in the DIRC3 gene, including its relationship with unfavorable histopathological and clinical features and mortality, in differentiated thyroid cancer (DTC). The study included 1466 patients diagnosed with DTC from one center. There was no significant association between the DIRC3 genotype at rs966423 (CC, CT, or TT) and any histopathological or clinic factor examined, including initial response to therapy, response at follow-up, or overall mortality, in DTC patients. MDPI 2020-02-12 /pmc/articles/PMC7072153/ /pubmed/32059462 http://dx.doi.org/10.3390/cancers12020423 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hińcza, Kinga
Kowalik, Artur
Pałyga, Iwona
Walczyk, Agnieszka
Gąsior-Perczak, Danuta
Mikina, Estera
Trybek, Tomasz
Szymonek, Monika
Gadawska-Juszczyk, Klaudia
Zajkowska, Klaudia
Suligowska, Agnieszka
Kuchareczko, Artur
Krawczyk, Karol
Kopczyński, Janusz
Chrapek, Magdalena
Góźdź, Stanisław
Kowalska, Aldona
Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title_full Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title_fullStr Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title_full_unstemmed Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title_short Does the TT Variant of the rs966423 Polymorphism in DIRC3 Affect the Stage and Clinical Course of Papillary Thyroid Cancer?
title_sort does the tt variant of the rs966423 polymorphism in dirc3 affect the stage and clinical course of papillary thyroid cancer?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072153/
https://www.ncbi.nlm.nih.gov/pubmed/32059462
http://dx.doi.org/10.3390/cancers12020423
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