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PPAR-Mediated Toxicology and Applied Pharmacology

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as t...

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Autores principales: Xi, Yue, Zhang, Yunhui, Zhu, Sirui, Luo, Yuping, Xu, Pengfei, Huang, Zhiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072218/
https://www.ncbi.nlm.nih.gov/pubmed/32028670
http://dx.doi.org/10.3390/cells9020352
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author Xi, Yue
Zhang, Yunhui
Zhu, Sirui
Luo, Yuping
Xu, Pengfei
Huang, Zhiying
author_facet Xi, Yue
Zhang, Yunhui
Zhu, Sirui
Luo, Yuping
Xu, Pengfei
Huang, Zhiying
author_sort Xi, Yue
collection PubMed
description Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology.
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spelling pubmed-70722182020-03-19 PPAR-Mediated Toxicology and Applied Pharmacology Xi, Yue Zhang, Yunhui Zhu, Sirui Luo, Yuping Xu, Pengfei Huang, Zhiying Cells Review Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology. MDPI 2020-02-03 /pmc/articles/PMC7072218/ /pubmed/32028670 http://dx.doi.org/10.3390/cells9020352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xi, Yue
Zhang, Yunhui
Zhu, Sirui
Luo, Yuping
Xu, Pengfei
Huang, Zhiying
PPAR-Mediated Toxicology and Applied Pharmacology
title PPAR-Mediated Toxicology and Applied Pharmacology
title_full PPAR-Mediated Toxicology and Applied Pharmacology
title_fullStr PPAR-Mediated Toxicology and Applied Pharmacology
title_full_unstemmed PPAR-Mediated Toxicology and Applied Pharmacology
title_short PPAR-Mediated Toxicology and Applied Pharmacology
title_sort ppar-mediated toxicology and applied pharmacology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072218/
https://www.ncbi.nlm.nih.gov/pubmed/32028670
http://dx.doi.org/10.3390/cells9020352
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