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PPAR-Mediated Toxicology and Applied Pharmacology
Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072218/ https://www.ncbi.nlm.nih.gov/pubmed/32028670 http://dx.doi.org/10.3390/cells9020352 |
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author | Xi, Yue Zhang, Yunhui Zhu, Sirui Luo, Yuping Xu, Pengfei Huang, Zhiying |
author_facet | Xi, Yue Zhang, Yunhui Zhu, Sirui Luo, Yuping Xu, Pengfei Huang, Zhiying |
author_sort | Xi, Yue |
collection | PubMed |
description | Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology. |
format | Online Article Text |
id | pubmed-7072218 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70722182020-03-19 PPAR-Mediated Toxicology and Applied Pharmacology Xi, Yue Zhang, Yunhui Zhu, Sirui Luo, Yuping Xu, Pengfei Huang, Zhiying Cells Review Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone receptor family, attract wide attention as promising therapeutic targets for the treatment of multiple diseases, and their target selective ligands were also intensively developed for pharmacological agents such as the approved drugs fibrates and thiazolidinediones (TZDs). Despite their potent pharmacological activities, PPARs are reported to be involved in agent- and pollutant-induced multiple organ toxicity or protective effects against toxicity. A better understanding of the protective and the detrimental role of PPARs will help to preserve efficacy of the PPAR modulators but diminish adverse effects. The present review summarizes and critiques current findings related to PPAR-mediated types of toxicity and protective effects against toxicity for a systematic understanding of PPARs in toxicology and applied pharmacology. MDPI 2020-02-03 /pmc/articles/PMC7072218/ /pubmed/32028670 http://dx.doi.org/10.3390/cells9020352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Xi, Yue Zhang, Yunhui Zhu, Sirui Luo, Yuping Xu, Pengfei Huang, Zhiying PPAR-Mediated Toxicology and Applied Pharmacology |
title | PPAR-Mediated Toxicology and Applied Pharmacology |
title_full | PPAR-Mediated Toxicology and Applied Pharmacology |
title_fullStr | PPAR-Mediated Toxicology and Applied Pharmacology |
title_full_unstemmed | PPAR-Mediated Toxicology and Applied Pharmacology |
title_short | PPAR-Mediated Toxicology and Applied Pharmacology |
title_sort | ppar-mediated toxicology and applied pharmacology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072218/ https://www.ncbi.nlm.nih.gov/pubmed/32028670 http://dx.doi.org/10.3390/cells9020352 |
work_keys_str_mv | AT xiyue pparmediatedtoxicologyandappliedpharmacology AT zhangyunhui pparmediatedtoxicologyandappliedpharmacology AT zhusirui pparmediatedtoxicologyandappliedpharmacology AT luoyuping pparmediatedtoxicologyandappliedpharmacology AT xupengfei pparmediatedtoxicologyandappliedpharmacology AT huangzhiying pparmediatedtoxicologyandappliedpharmacology |