Cargando…

Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis

Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Decmann, Abel, Perge, Pál, Turai, Peter Istvan, Patócs, Attila, Igaz, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072220/
https://www.ncbi.nlm.nih.gov/pubmed/32079166
http://dx.doi.org/10.3390/cancers12020461
_version_ 1783506355719503872
author Decmann, Abel
Perge, Pál
Turai, Peter Istvan
Patócs, Attila
Igaz, Peter
author_facet Decmann, Abel
Perge, Pál
Turai, Peter Istvan
Patócs, Attila
Igaz, Peter
author_sort Decmann, Abel
collection PubMed
description Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and there are no reliable blood-borne markers of adrenocortical malignancy, either. Several findings show the potential applicability of microRNAs as biomarkers of malignancy and prognosis, and there are some data on lncRNA as well. In this review, we present a synopsis on the potential relevance of non-coding RNA molecules in adrenocortical pathogenesis and their applicability in diagnosis from tissue and blood.
format Online
Article
Text
id pubmed-7072220
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70722202020-03-19 Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis Decmann, Abel Perge, Pál Turai, Peter Istvan Patócs, Attila Igaz, Peter Cancers (Basel) Review Non-coding RNA molecules including microRNAs and long non-coding RNAs (lncRNA) have been implicated in the pathogenesis of several tumors and numerous data support their applicability in diagnosis as well. Despite recent advances, the pathogenesis of adrenocortical cancer still remains elusive and there are no reliable blood-borne markers of adrenocortical malignancy, either. Several findings show the potential applicability of microRNAs as biomarkers of malignancy and prognosis, and there are some data on lncRNA as well. In this review, we present a synopsis on the potential relevance of non-coding RNA molecules in adrenocortical pathogenesis and their applicability in diagnosis from tissue and blood. MDPI 2020-02-17 /pmc/articles/PMC7072220/ /pubmed/32079166 http://dx.doi.org/10.3390/cancers12020461 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Decmann, Abel
Perge, Pál
Turai, Peter Istvan
Patócs, Attila
Igaz, Peter
Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title_full Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title_fullStr Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title_full_unstemmed Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title_short Non-Coding RNAs in Adrenocortical Cancer: From Pathogenesis to Diagnosis
title_sort non-coding rnas in adrenocortical cancer: from pathogenesis to diagnosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072220/
https://www.ncbi.nlm.nih.gov/pubmed/32079166
http://dx.doi.org/10.3390/cancers12020461
work_keys_str_mv AT decmannabel noncodingrnasinadrenocorticalcancerfrompathogenesistodiagnosis
AT pergepal noncodingrnasinadrenocorticalcancerfrompathogenesistodiagnosis
AT turaipeteristvan noncodingrnasinadrenocorticalcancerfrompathogenesistodiagnosis
AT patocsattila noncodingrnasinadrenocorticalcancerfrompathogenesistodiagnosis
AT igazpeter noncodingrnasinadrenocorticalcancerfrompathogenesistodiagnosis