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Emerging Roles of ALK in Immunity and Insights for Immunotherapy
Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherap...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072244/ https://www.ncbi.nlm.nih.gov/pubmed/32059449 http://dx.doi.org/10.3390/cancers12020426 |
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author | Wang, Lan Lui, Vivian Wai Yan |
author_facet | Wang, Lan Lui, Vivian Wai Yan |
author_sort | Wang, Lan |
collection | PubMed |
description | Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers. |
format | Online Article Text |
id | pubmed-7072244 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70722442020-03-19 Emerging Roles of ALK in Immunity and Insights for Immunotherapy Wang, Lan Lui, Vivian Wai Yan Cancers (Basel) Review Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers. MDPI 2020-02-12 /pmc/articles/PMC7072244/ /pubmed/32059449 http://dx.doi.org/10.3390/cancers12020426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Lan Lui, Vivian Wai Yan Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title | Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title_full | Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title_fullStr | Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title_full_unstemmed | Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title_short | Emerging Roles of ALK in Immunity and Insights for Immunotherapy |
title_sort | emerging roles of alk in immunity and insights for immunotherapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072244/ https://www.ncbi.nlm.nih.gov/pubmed/32059449 http://dx.doi.org/10.3390/cancers12020426 |
work_keys_str_mv | AT wanglan emergingrolesofalkinimmunityandinsightsforimmunotherapy AT luivivianwaiyan emergingrolesofalkinimmunityandinsightsforimmunotherapy |