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Emerging Roles of ALK in Immunity and Insights for Immunotherapy

Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherap...

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Detalles Bibliográficos
Autores principales: Wang, Lan, Lui, Vivian Wai Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072244/
https://www.ncbi.nlm.nih.gov/pubmed/32059449
http://dx.doi.org/10.3390/cancers12020426
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author Wang, Lan
Lui, Vivian Wai Yan
author_facet Wang, Lan
Lui, Vivian Wai Yan
author_sort Wang, Lan
collection PubMed
description Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers.
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spelling pubmed-70722442020-03-19 Emerging Roles of ALK in Immunity and Insights for Immunotherapy Wang, Lan Lui, Vivian Wai Yan Cancers (Basel) Review Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. Here, we provide a timely review on the most updated laboratory and patient-related findings on ALK and immunity, which would grant us important insights for the development of novel ALK immunotherapies for ALK-altered cancers. MDPI 2020-02-12 /pmc/articles/PMC7072244/ /pubmed/32059449 http://dx.doi.org/10.3390/cancers12020426 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Lan
Lui, Vivian Wai Yan
Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title_full Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title_fullStr Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title_full_unstemmed Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title_short Emerging Roles of ALK in Immunity and Insights for Immunotherapy
title_sort emerging roles of alk in immunity and insights for immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072244/
https://www.ncbi.nlm.nih.gov/pubmed/32059449
http://dx.doi.org/10.3390/cancers12020426
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