A Bispecific Inhibitor of the EGFR/ADAM17 Axis Decreases Cell Proliferation and Migration of EGFR-Dependent Cancer Cells

Dysregulated epidermal growth factor receptor (EGFR) is an oncogenic driver of many human cancers, promoting aberrant cell proliferation, migration, and survival. Pharmacological targeting of EGFR is often challenged by acquired mechanisms of resistance. Ligand-dependent mechanisms in EGFR wild-type...

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Detalles Bibliográficos
Autores principales: Soto-Gamez, Abel, Chen, Deng, Nabuurs, Anke G.E., Quax, Wim J., Demaria, Marco, Boersma, Ykelien L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072247/
https://www.ncbi.nlm.nih.gov/pubmed/32050662
http://dx.doi.org/10.3390/cancers12020411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072247/
https://www.ncbi.nlm.nih.gov/pubmed/32050662
http://dx.doi.org/10.3390/cancers12020411

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