Cargando…

PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPARγ at Ser273

Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPARγ at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK) orchestrates diabetic gene reprogramming via dysregulation of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khim, Keon Woo, Choi, Sun Sil, Jang, Hyun-Jun, Lee, Yo Han, Lee, Eujin, Hyun, Ji-Min, Eom, Hye-Jin, Yoon, Sora, Choi, Jeong-Won, Park, Tae-Eun, Nam, Dougu, Choi, Jang Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072254/ https://www.ncbi.nlm.nih.gov/pubmed/32024237 http://dx.doi.org/10.3390/cells9020343

Ejemplares similares

The E3 ubiquitin ligase TRIM25 regulates adipocyte differentiation via proteasome-mediated degradation of PPARγ
por: Lee, Jae Min, et al.
Publicado: (2018)

Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming
por: Choi, Jang Hyun, et al.
Publicado: (2014)

Revisiting PPARγ as a target for the treatment of metabolic disorders
por: Choi, Sun-Sil, et al.
Publicado: (2014)

Hepatic MIR20B promotes nonalcoholic fatty liver disease by suppressing PPARA
por: Lee, Yo Han, et al.
Publicado: (2021)

3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγ Ser273 phosphorylation in type 2 diabetic mice
por: Zhang, Yudian, et al.
Publicado: (2023)

Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands
por: Bae, Hwan, et al.
Publicado: (2016)

Obesity-Linked PPARγ Ser273 Phosphorylation Promotes Beneficial Effects on the Liver, despite Reduced Insulin Sensitivity in Mice
por: Terra, Maiara Ferreira, et al.
Publicado: (2023)

Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca(2+) homeostasis
por: Choi, Sun Sil, et al.
Publicado: (2020)

PPARγ S273 Phosphorylation Modifies the Dynamics of Coregulator Proteins Recruitment
por: Dias, Marieli Mariano Gonçalves, et al.
Publicado: (2020)

Lipid Droplet Formation Is Regulated by Ser/Thr Phosphatase PPM1D via Dephosphorylation of Perilipin 1
por: Kamada, Rui, et al.
Publicado: (2022)

Broussonetia papyrifera Root Bark Extract Exhibits Anti-inflammatory Effects on Adipose Tissue and Improves Insulin Sensitivity Potentially Via AMPK Activation
por: Lee, Jae Min, et al.
Publicado: (2020)

Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation
por: Lee, Ye Hyung, et al.
Publicado: (2021)

Obesity-linked phosphorylation of PPARγ by cdk5 is a direct target of the anti-diabetic PPARγ ligands
por: Choi, Jang Hyun, et al.
Publicado: (2010)

Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
por: Jang, Jun Young, et al.
Publicado: (2018)

Suppression of Adipocyte Differentiation by Foenumoside B from Lysimachia foenum-graecum Is Mediated by PPARγ Antagonism
por: Kwak, Hyun Jeong, et al.
Publicado: (2016)

Structural Basis for the Regulation of PPARγ Activity by Imatinib
por: Jang, Jun Young, et al.
Publicado: (2019)

Thrap3 promotes nonalcoholic fatty liver disease by suppressing AMPK-mediated autophagy
por: Jang, Hyun-Jun, et al.
Publicado: (2023)

DHA increases adiponectin expression more effectively than EPA at relative low concentrations by regulating PPARγ and its phosphorylation at Ser273 in 3T3-L1 adipocytes
por: Song, Jia, et al.
Publicado: (2017)

CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis
por: Jang, Min Jun, et al.
Publicado: (2017)

Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
por: Hua, Tuyen N.M., et al.
Publicado: (2019)

Differential Effects of Cancer-Associated Mutations Enriched in Helix H3 of PPARγ
por: Jang, Dong Man, et al.
Publicado: (2020)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
por: Berndsen, Kerryn, et al.
Publicado: (2019)

CDDO, a PPAR-γ ligand, inhibits TPA-induced cell migration and invasion through a PPAR-γ-independent mechanism
por: Jang, Hye-Yeon, et al.
Publicado: (2022)

Dephosphorylation of survival motor neurons (SMN) by PPM1G/PP2Cγ governs Cajal body localization and stability of the SMN complex
por: Petri, Sebastian, et al.
Publicado: (2007)

PPAR-δ agonist affects adipo-chondrogenic differentiation of human mesenchymal stem cells through the expression of PPAR-γ
por: Kim, Dong Hyun, et al.
Publicado: (2020)

The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration
por: Zhou, Ruyuan, et al.
Publicado: (2021)

Wip1 suppresses apoptotic cell death through direct dephosphorylation of BAX in response to γ-radiation
por: Song, J-Y, et al.
Publicado: (2013)

Protein Phosphatase 1 Dephosphorylates Profilin-1 at Ser-137
por: Shao, Jieya, et al.
Publicado: (2012)

Comparative analysis of shipboard three-component magnetometer (STCM) and proton precession magnetometer (PPM) datasets in the Australian-Antarctic Ridge
por: Choi, Hakkyum, et al.
Publicado: (2023)

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175
por: Ammosova, Tatiana, et al.
Publicado: (2011)

PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1
por: Xiang, Weiwen, et al.
Publicado: (2016)

Gene dispersion is the key determinant of the read count bias in differential expression analysis of RNA-seq data
por: Yoon, Sora, et al.
Publicado: (2017)

PPARγ sumoylation-mediated lipid accumulation in lung cancer
por: Phan, Ai N.H., et al.
Publicado: (2017)

T-Cell Death-Associated Gene 51 Is a Novel Negative Regulator of PPARγ That Inhibits PPARγ-RXRα Heterodimer Formation in Adipogenesis
por: Kim, Sumi, et al.
Publicado: (2021)

SPIN90 dephosphorylation is required for cofilin-mediated actin depolymerization in NMDA-stimulated hippocampal neurons
por: Cho, In Ha, et al.
Publicado: (2013)

Structural basis for the inhibitory effects of a novel reversible covalent ligand on PPARγ phosphorylation
por: Jang, Jun Young, et al.
Publicado: (2019)

PS273. Seasonality of suicide mortality and climate variables from 1992 to 2010 in South Korea
por: Jee, Hee-Jung, et al.
Publicado: (2016)

Transcriptional Regulator TonEBP Mediates Oxidative Damages in Ischemic Kidney Injury
por: Yoo, Eun Jin, et al.
Publicado: (2019)

Synthesis of Phthalimide Derivatives as Potential PPAR-γ Ligands
por: Eom, So Hyeon, et al.
Publicado: (2016)

Protein serine/threonine phosphatase PPEF-1 suppresses genotoxic stress response via dephosphorylation of PDCD5
por: Park, Soo-Yeon, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bmptl32ohto9drmgj5c0qka9qt