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NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models

Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using a...

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Autores principales: McDonald, J. Tyson, Stainforth, Robert, Miller, Jack, Cahill, Thomas, da Silveira, Willian A., Rathi, Komal S., Hardiman, Gary, Taylor, Deanne, Costes, Sylvain V., Chauhan, Vinita, Meller, Robert, Beheshti, Afshin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072278/
https://www.ncbi.nlm.nih.gov/pubmed/32045996
http://dx.doi.org/10.3390/cancers12020381
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author McDonald, J. Tyson
Stainforth, Robert
Miller, Jack
Cahill, Thomas
da Silveira, Willian A.
Rathi, Komal S.
Hardiman, Gary
Taylor, Deanne
Costes, Sylvain V.
Chauhan, Vinita
Meller, Robert
Beheshti, Afshin
author_facet McDonald, J. Tyson
Stainforth, Robert
Miller, Jack
Cahill, Thomas
da Silveira, Willian A.
Rathi, Komal S.
Hardiman, Gary
Taylor, Deanne
Costes, Sylvain V.
Chauhan, Vinita
Meller, Robert
Beheshti, Afshin
author_sort McDonald, J. Tyson
collection PubMed
description Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures.
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spelling pubmed-70722782020-03-19 NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models McDonald, J. Tyson Stainforth, Robert Miller, Jack Cahill, Thomas da Silveira, Willian A. Rathi, Komal S. Hardiman, Gary Taylor, Deanne Costes, Sylvain V. Chauhan, Vinita Meller, Robert Beheshti, Afshin Cancers (Basel) Article Background: Ionizing radiation from galactic cosmic rays (GCR) is one of the major risk factors that will impact the health of astronauts on extended missions outside the protective effects of the Earth’s magnetic field. The NASA GeneLab project has detailed information on radiation exposure using animal models with curated dosimetry information for spaceflight experiments. Methods: We analyzed multiple GeneLab omics datasets associated with both ground-based and spaceflight radiation studies that included in vivo and in vitro approaches. A range of ions from protons to iron particles with doses from 0.1 to 1.0 Gy for ground studies, as well as samples flown in low Earth orbit (LEO) with total doses of 1.0 mGy to 30 mGy, were utilized. Results: From this analysis, we were able to identify distinct biological signatures associating specific ions with specific biological responses due to radiation exposure in space. For example, we discovered changes in mitochondrial function, ribosomal assembly, and immune pathways as a function of dose. Conclusions: We provided a summary of how the GeneLab’s rich database of omics experiments with animal models can be used to generate novel hypotheses to better understand human health risks from GCR exposures. MDPI 2020-02-07 /pmc/articles/PMC7072278/ /pubmed/32045996 http://dx.doi.org/10.3390/cancers12020381 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
McDonald, J. Tyson
Stainforth, Robert
Miller, Jack
Cahill, Thomas
da Silveira, Willian A.
Rathi, Komal S.
Hardiman, Gary
Taylor, Deanne
Costes, Sylvain V.
Chauhan, Vinita
Meller, Robert
Beheshti, Afshin
NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title_full NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title_fullStr NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title_full_unstemmed NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title_short NASA GeneLab Platform Utilized for Biological Response to Space Radiation in Animal Models
title_sort nasa genelab platform utilized for biological response to space radiation in animal models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072278/
https://www.ncbi.nlm.nih.gov/pubmed/32045996
http://dx.doi.org/10.3390/cancers12020381
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