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Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease

Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the...

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Autores principales: Llorens, Franc, Villar-Piqué, Anna, Hermann, Peter, Schmitz, Matthias, Calero, Olga, Stehmann, Christiane, Sarros, Shannon, Moda, Fabio, Ferrer, Isidre, Poleggi, Anna, Pocchiari, Maurizio, Catania, Marcella, Klotz, Sigrid, O’Regan, Carl, Brett, Francesca, Heffernan, Josephine, Ladogana, Anna, Collins, Steven J., Calero, Miguel, Kovacs, Gabor G., Zerr, Inga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072321/
https://www.ncbi.nlm.nih.gov/pubmed/32059611
http://dx.doi.org/10.3390/biom10020290
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author Llorens, Franc
Villar-Piqué, Anna
Hermann, Peter
Schmitz, Matthias
Calero, Olga
Stehmann, Christiane
Sarros, Shannon
Moda, Fabio
Ferrer, Isidre
Poleggi, Anna
Pocchiari, Maurizio
Catania, Marcella
Klotz, Sigrid
O’Regan, Carl
Brett, Francesca
Heffernan, Josephine
Ladogana, Anna
Collins, Steven J.
Calero, Miguel
Kovacs, Gabor G.
Zerr, Inga
author_facet Llorens, Franc
Villar-Piqué, Anna
Hermann, Peter
Schmitz, Matthias
Calero, Olga
Stehmann, Christiane
Sarros, Shannon
Moda, Fabio
Ferrer, Isidre
Poleggi, Anna
Pocchiari, Maurizio
Catania, Marcella
Klotz, Sigrid
O’Regan, Carl
Brett, Francesca
Heffernan, Josephine
Ladogana, Anna
Collins, Steven J.
Calero, Miguel
Kovacs, Gabor G.
Zerr, Inga
author_sort Llorens, Franc
collection PubMed
description Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases.
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spelling pubmed-70723212020-03-19 Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease Llorens, Franc Villar-Piqué, Anna Hermann, Peter Schmitz, Matthias Calero, Olga Stehmann, Christiane Sarros, Shannon Moda, Fabio Ferrer, Isidre Poleggi, Anna Pocchiari, Maurizio Catania, Marcella Klotz, Sigrid O’Regan, Carl Brett, Francesca Heffernan, Josephine Ladogana, Anna Collins, Steven J. Calero, Miguel Kovacs, Gabor G. Zerr, Inga Biomolecules Article Human prion diseases are classified into sporadic, genetic, and acquired forms. Within this last group, iatrogenic Creutzfeldt–Jakob disease (iCJD) is caused by human-to-human transmission through surgical and medical procedures. After reaching an incidence peak in the 1990s, it is believed that the iCJD historical period is probably coming to an end, thanks to lessons learnt from past infection sources that promoted new prion prevention and decontamination protocols. At this point, we sought to characterise the biomarker profile of iCJD and compare it to that of sporadic CJD (sCJD) for determining the value of available diagnostic tools in promptly recognising iCJD cases. To that end, we collected 23 iCJD samples from seven national CJD surveillance centres and analysed the electroencephalogram and neuroimaging data together with a panel of seven CSF biomarkers: 14-3-3, total tau, phosphorylated/total tau ratio, alpha-synuclein, neurofilament light, YKL-40, and real-time quaking induced conversion of prion protein. Using the cut-off values established for sCJD, we found the sensitivities of these biomarkers for iCJD to be similar to those described for sCJD. Given the limited relevant information on this issue to date, the present study validates the use of current sCJD biomarkers for the diagnosis of future iCJD cases. MDPI 2020-02-12 /pmc/articles/PMC7072321/ /pubmed/32059611 http://dx.doi.org/10.3390/biom10020290 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Llorens, Franc
Villar-Piqué, Anna
Hermann, Peter
Schmitz, Matthias
Calero, Olga
Stehmann, Christiane
Sarros, Shannon
Moda, Fabio
Ferrer, Isidre
Poleggi, Anna
Pocchiari, Maurizio
Catania, Marcella
Klotz, Sigrid
O’Regan, Carl
Brett, Francesca
Heffernan, Josephine
Ladogana, Anna
Collins, Steven J.
Calero, Miguel
Kovacs, Gabor G.
Zerr, Inga
Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title_full Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title_fullStr Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title_full_unstemmed Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title_short Diagnostic Accuracy of Prion Disease Biomarkers in Iatrogenic Creutzfeldt-Jakob Disease
title_sort diagnostic accuracy of prion disease biomarkers in iatrogenic creutzfeldt-jakob disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072321/
https://www.ncbi.nlm.nih.gov/pubmed/32059611
http://dx.doi.org/10.3390/biom10020290
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