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Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072361/ https://www.ncbi.nlm.nih.gov/pubmed/32046309 http://dx.doi.org/10.3390/cancers12020396 |
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author | Tamayo-Orbegozo, Estíbaliz Amo, Laura Díez-García, Javier Amutio, Elena Riñón, Marta Alonso, Marta Arana, Paula Maruri, Natalia Larrucea, Susana |
author_facet | Tamayo-Orbegozo, Estíbaliz Amo, Laura Díez-García, Javier Amutio, Elena Riñón, Marta Alonso, Marta Arana, Paula Maruri, Natalia Larrucea, Susana |
author_sort | Tamayo-Orbegozo, Estíbaliz |
collection | PubMed |
description | Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression. |
format | Online Article Text |
id | pubmed-7072361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70723612020-03-19 Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma Tamayo-Orbegozo, Estíbaliz Amo, Laura Díez-García, Javier Amutio, Elena Riñón, Marta Alonso, Marta Arana, Paula Maruri, Natalia Larrucea, Susana Cancers (Basel) Review Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression. MDPI 2020-02-08 /pmc/articles/PMC7072361/ /pubmed/32046309 http://dx.doi.org/10.3390/cancers12020396 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tamayo-Orbegozo, Estíbaliz Amo, Laura Díez-García, Javier Amutio, Elena Riñón, Marta Alonso, Marta Arana, Paula Maruri, Natalia Larrucea, Susana Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title_full | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title_fullStr | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title_full_unstemmed | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title_short | Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma |
title_sort | emerging role of podocalyxin in the progression of mature b-cell non-hodgkin lymphoma |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072361/ https://www.ncbi.nlm.nih.gov/pubmed/32046309 http://dx.doi.org/10.3390/cancers12020396 |
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