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Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma

Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse...

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Autores principales: Tamayo-Orbegozo, Estíbaliz, Amo, Laura, Díez-García, Javier, Amutio, Elena, Riñón, Marta, Alonso, Marta, Arana, Paula, Maruri, Natalia, Larrucea, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072361/
https://www.ncbi.nlm.nih.gov/pubmed/32046309
http://dx.doi.org/10.3390/cancers12020396
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author Tamayo-Orbegozo, Estíbaliz
Amo, Laura
Díez-García, Javier
Amutio, Elena
Riñón, Marta
Alonso, Marta
Arana, Paula
Maruri, Natalia
Larrucea, Susana
author_facet Tamayo-Orbegozo, Estíbaliz
Amo, Laura
Díez-García, Javier
Amutio, Elena
Riñón, Marta
Alonso, Marta
Arana, Paula
Maruri, Natalia
Larrucea, Susana
author_sort Tamayo-Orbegozo, Estíbaliz
collection PubMed
description Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression.
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spelling pubmed-70723612020-03-19 Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma Tamayo-Orbegozo, Estíbaliz Amo, Laura Díez-García, Javier Amutio, Elena Riñón, Marta Alonso, Marta Arana, Paula Maruri, Natalia Larrucea, Susana Cancers (Basel) Review Mature B-cell non-Hodgkin lymphoma (B-NHL) constitutes a group of heterogeneous malignant lymphoproliferative diseases ranging from indolent to highly aggressive forms. Although the survival after chemo-immunotherapy treatment of mature B-NHL has increased over the last years, many patients relapse or remain refractory due to drug resistance, presenting an unfavorable prognosis. Hence, there is an urgent need to identify new prognostic markers and therapeutic targets. Podocalyxin (PODXL), a sialomucin overexpressed in a variety of tumor cell types and associated with their aggressiveness, has been implicated in multiple aspects of cancer progression, although its participation in hematological malignancies remains unexplored. New evidence points to a role for PODXL in mature B-NHL cell proliferation, survival, migration, drug resistance, and metabolic reprogramming, as well as enhanced levels of PODXL in mature B-NHL. Here, we review the current knowledge on the contribution of PODXL to tumorigenesis, highlighting and discussing its role in mature B-NHL progression. MDPI 2020-02-08 /pmc/articles/PMC7072361/ /pubmed/32046309 http://dx.doi.org/10.3390/cancers12020396 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tamayo-Orbegozo, Estíbaliz
Amo, Laura
Díez-García, Javier
Amutio, Elena
Riñón, Marta
Alonso, Marta
Arana, Paula
Maruri, Natalia
Larrucea, Susana
Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title_full Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title_fullStr Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title_full_unstemmed Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title_short Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma
title_sort emerging role of podocalyxin in the progression of mature b-cell non-hodgkin lymphoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072361/
https://www.ncbi.nlm.nih.gov/pubmed/32046309
http://dx.doi.org/10.3390/cancers12020396
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