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The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer
Prostate cancer (PCa) is the second most common cancer of men and is typically slow-growing and asymptomatic. The use of blood PSA as a screening method has greatly improved PCa diagnosis, but high levels of false positives has raised much interest in alternative biomarkers. We used next-generation...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072374/ https://www.ncbi.nlm.nih.gov/pubmed/32098402 http://dx.doi.org/10.3390/cancers12020513 |
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author | Solé, Carla Goicoechea, Ibai Goñi, Alai Schramm, Maike Armesto, María Arestin, María Manterola, Lorea Tellaetxe, Maitena Alberdi, Aitor Nogueira, Leonor Roumiguie, Mathieu López, Jose Ignacio Sanz Jaka, Juan Pablo Urruticoechea, Ander Vergara, Itziar Loizaga-Iriarte, Ana Unda, Miguel Carracedo, Arkaitz Malavaud, Bernard Lawrie, Charles H. |
author_facet | Solé, Carla Goicoechea, Ibai Goñi, Alai Schramm, Maike Armesto, María Arestin, María Manterola, Lorea Tellaetxe, Maitena Alberdi, Aitor Nogueira, Leonor Roumiguie, Mathieu López, Jose Ignacio Sanz Jaka, Juan Pablo Urruticoechea, Ander Vergara, Itziar Loizaga-Iriarte, Ana Unda, Miguel Carracedo, Arkaitz Malavaud, Bernard Lawrie, Charles H. |
author_sort | Solé, Carla |
collection | PubMed |
description | Prostate cancer (PCa) is the second most common cancer of men and is typically slow-growing and asymptomatic. The use of blood PSA as a screening method has greatly improved PCa diagnosis, but high levels of false positives has raised much interest in alternative biomarkers. We used next-generation sequencing (NGS) to elucidate the urinary transcriptome of whole urine collected from high-stage and low-stage PCa patients as well as from patients with the confounding diagnosis of benign hyperplasia (BPH). We identified and validated five differentially expressed protein-coding genes (FTH1 BRPF1, OSBP, PHC3, and UACA) in an independent validation cohort of small-volume (1 mL) centrifuged urine (n = 94) and non-centrifuged urine (n = 84) by droplet digital (dd)PCR. These biomarkers were able to discriminate between BPH and PCa patients and healthy controls using either centrifuged or non-centrifuged whole urine samples, suggesting that the urinary transcriptome is a valuable source of non-invasive biomarkers for PCa that warrants further investigation. |
format | Online Article Text |
id | pubmed-7072374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70723742020-03-19 The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer Solé, Carla Goicoechea, Ibai Goñi, Alai Schramm, Maike Armesto, María Arestin, María Manterola, Lorea Tellaetxe, Maitena Alberdi, Aitor Nogueira, Leonor Roumiguie, Mathieu López, Jose Ignacio Sanz Jaka, Juan Pablo Urruticoechea, Ander Vergara, Itziar Loizaga-Iriarte, Ana Unda, Miguel Carracedo, Arkaitz Malavaud, Bernard Lawrie, Charles H. Cancers (Basel) Article Prostate cancer (PCa) is the second most common cancer of men and is typically slow-growing and asymptomatic. The use of blood PSA as a screening method has greatly improved PCa diagnosis, but high levels of false positives has raised much interest in alternative biomarkers. We used next-generation sequencing (NGS) to elucidate the urinary transcriptome of whole urine collected from high-stage and low-stage PCa patients as well as from patients with the confounding diagnosis of benign hyperplasia (BPH). We identified and validated five differentially expressed protein-coding genes (FTH1 BRPF1, OSBP, PHC3, and UACA) in an independent validation cohort of small-volume (1 mL) centrifuged urine (n = 94) and non-centrifuged urine (n = 84) by droplet digital (dd)PCR. These biomarkers were able to discriminate between BPH and PCa patients and healthy controls using either centrifuged or non-centrifuged whole urine samples, suggesting that the urinary transcriptome is a valuable source of non-invasive biomarkers for PCa that warrants further investigation. MDPI 2020-02-22 /pmc/articles/PMC7072374/ /pubmed/32098402 http://dx.doi.org/10.3390/cancers12020513 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Solé, Carla Goicoechea, Ibai Goñi, Alai Schramm, Maike Armesto, María Arestin, María Manterola, Lorea Tellaetxe, Maitena Alberdi, Aitor Nogueira, Leonor Roumiguie, Mathieu López, Jose Ignacio Sanz Jaka, Juan Pablo Urruticoechea, Ander Vergara, Itziar Loizaga-Iriarte, Ana Unda, Miguel Carracedo, Arkaitz Malavaud, Bernard Lawrie, Charles H. The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title | The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title_full | The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title_fullStr | The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title_full_unstemmed | The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title_short | The Urinary Transcriptome as a Source of Biomarkers for Prostate Cancer |
title_sort | urinary transcriptome as a source of biomarkers for prostate cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072374/ https://www.ncbi.nlm.nih.gov/pubmed/32098402 http://dx.doi.org/10.3390/cancers12020513 |
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