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Targeting NRF2-Governed Glutathione Synthesis for SDHB-Mutated Pheochromocytoma and Paraganglioma

Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). SDHB-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated levels of reactive ox...

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Detalles Bibliográficos
Autores principales:	Liu, Yang, Pang, Ying, Caisova, Veronika, Ding, Jianyi, Yu, Di, Zhou, Yiqiang, Huynh, Thanh-Truc, Ghayee, Hans, Pacak, Karel, Yang, Chunzhang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072390/ https://www.ncbi.nlm.nih.gov/pubmed/31979226 http://dx.doi.org/10.3390/cancers12020280

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