Cargando…
hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay
In the last decade, Nerve Growth Factor (NGF)-based clinical approaches have lacked specific and efficient Tyrosine Kinase A (TrkA) agonists for brain delivery. Nowadays, the characterization of novel small peptidomimetic is taking centre stage in preclinical studies, in order to overcome the main s...
Autores principales: | Triaca, Viviana, Fico, Elena, Sposato, Valentina, Caioli, Silvia, Ciotti, Maria Teresa, Zona, Cristina, Mercanti, Delio, La Mendola, Diego, Satriano, Cristina, Rizzarelli, Enrico, Tirassa, Paola, Calissano, Pietro |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072391/ https://www.ncbi.nlm.nih.gov/pubmed/32024191 http://dx.doi.org/10.3390/biom10020216 |
Ejemplares similares
-
Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons
por: Latina, Valentina, et al.
Publicado: (2017) -
Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents
por: Canu, Nadia, et al.
Publicado: (2017) -
The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer’s Disease Neuropathology
por: Canu, Nadia, et al.
Publicado: (2017) -
NGF Prevents Loss of TrkA/VEGFR2 Cells, and VEGF Isoform Dysregulation in the Retina of Adult Diabetic Rats
por: Fico, Elena, et al.
Publicado: (2022) -
The Inorganic Side of NGF: Copper(II) and Zinc(II) Affect the NGF Mimicking Signaling of the N-Terminus Peptides Encompassing the Recognition Domain of TrkA Receptor
por: Pandini, Giuseppe, et al.
Publicado: (2016)