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Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance
Trastuzumab, a monoclonal antibody to human epidermal growth factor receptor 2 (HER2), has improved survival in patients with HER2-positive advanced gastric or gastroesophageal junction cancer (AGC). The inevitable development of resistance to trastuzumab remains a problem, however, with several tre...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072407/ https://www.ncbi.nlm.nih.gov/pubmed/32050652 http://dx.doi.org/10.3390/cancers12020400 |
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author | Mitani, Seiichiro Kawakami, Hisato |
author_facet | Mitani, Seiichiro Kawakami, Hisato |
author_sort | Mitani, Seiichiro |
collection | PubMed |
description | Trastuzumab, a monoclonal antibody to human epidermal growth factor receptor 2 (HER2), has improved survival in patients with HER2-positive advanced gastric or gastroesophageal junction cancer (AGC). The inevitable development of resistance to trastuzumab remains a problem, however, with several treatment strategies that have proven effective in breast cancer having failed to show clinical benefit in AGC. In this review, we summarize the mechanisms underlying resistance to HER2-targeted therapy and outline past and current challenges in the treatment of HER2-positive AGC refractory to trastuzumab. We further describe novel agents such as HER2 antibody–drug conjugates that are under development and have shown promising antitumor activity in early studies. |
format | Online Article Text |
id | pubmed-7072407 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70724072020-03-19 Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance Mitani, Seiichiro Kawakami, Hisato Cancers (Basel) Review Trastuzumab, a monoclonal antibody to human epidermal growth factor receptor 2 (HER2), has improved survival in patients with HER2-positive advanced gastric or gastroesophageal junction cancer (AGC). The inevitable development of resistance to trastuzumab remains a problem, however, with several treatment strategies that have proven effective in breast cancer having failed to show clinical benefit in AGC. In this review, we summarize the mechanisms underlying resistance to HER2-targeted therapy and outline past and current challenges in the treatment of HER2-positive AGC refractory to trastuzumab. We further describe novel agents such as HER2 antibody–drug conjugates that are under development and have shown promising antitumor activity in early studies. MDPI 2020-02-10 /pmc/articles/PMC7072407/ /pubmed/32050652 http://dx.doi.org/10.3390/cancers12020400 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mitani, Seiichiro Kawakami, Hisato Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title | Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title_full | Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title_fullStr | Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title_full_unstemmed | Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title_short | Emerging Targeted Therapies for HER2 Positive Gastric Cancer That Can Overcome Trastuzumab Resistance |
title_sort | emerging targeted therapies for her2 positive gastric cancer that can overcome trastuzumab resistance |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072407/ https://www.ncbi.nlm.nih.gov/pubmed/32050652 http://dx.doi.org/10.3390/cancers12020400 |
work_keys_str_mv | AT mitaniseiichiro emergingtargetedtherapiesforher2positivegastriccancerthatcanovercometrastuzumabresistance AT kawakamihisato emergingtargetedtherapiesforher2positivegastriccancerthatcanovercometrastuzumabresistance |