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Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and a...

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Autores principales: Allegra, Alessandro, Musolino, Caterina, Tonacci, Alessandro, Pioggia, Giovanni, Casciaro, Marco, Gangemi, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072434/
https://www.ncbi.nlm.nih.gov/pubmed/32102441
http://dx.doi.org/10.3390/cancers12020524
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author Allegra, Alessandro
Musolino, Caterina
Tonacci, Alessandro
Pioggia, Giovanni
Casciaro, Marco
Gangemi, Sebastiano
author_facet Allegra, Alessandro
Musolino, Caterina
Tonacci, Alessandro
Pioggia, Giovanni
Casciaro, Marco
Gangemi, Sebastiano
author_sort Allegra, Alessandro
collection PubMed
description B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and are decisive for its onset, evolution, and therapeutic response. Modifications in the cytokine balance could support the growth of the leukemic clone via a modulation of cellular proliferation and apoptosis, as some cytokines have been reported to be able to affect the life of B-CLL cells in vivo. In this review, we will examine the role played by cytokines in the cellular dynamics of B-CLL patients, interpret the contradictions sometimes present in the literature regarding their action, and evaluate the possibility of manipulating their production in order to intervene in the natural history of the disease.
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spelling pubmed-70724342020-03-19 Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role Allegra, Alessandro Musolino, Caterina Tonacci, Alessandro Pioggia, Giovanni Casciaro, Marco Gangemi, Sebastiano Cancers (Basel) Review B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and are decisive for its onset, evolution, and therapeutic response. Modifications in the cytokine balance could support the growth of the leukemic clone via a modulation of cellular proliferation and apoptosis, as some cytokines have been reported to be able to affect the life of B-CLL cells in vivo. In this review, we will examine the role played by cytokines in the cellular dynamics of B-CLL patients, interpret the contradictions sometimes present in the literature regarding their action, and evaluate the possibility of manipulating their production in order to intervene in the natural history of the disease. MDPI 2020-02-24 /pmc/articles/PMC7072434/ /pubmed/32102441 http://dx.doi.org/10.3390/cancers12020524 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Allegra, Alessandro
Musolino, Caterina
Tonacci, Alessandro
Pioggia, Giovanni
Casciaro, Marco
Gangemi, Sebastiano
Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title_full Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title_fullStr Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title_full_unstemmed Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title_short Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role
title_sort clinico-biological implications of modified levels of cytokines in chronic lymphocytic leukemia: a possible therapeutic role
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072434/
https://www.ncbi.nlm.nih.gov/pubmed/32102441
http://dx.doi.org/10.3390/cancers12020524
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