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Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia
Aberrant production of hydrogen sulfide (H(2)S) has been linked to preeclampsia. We hypothesized that sodium thiosulfate (STS), a H(2)S donor, reduces hypertension and proteinuria, and diminishes fetal growth restriction in the Dahl salt-sensitive (S) rat, a spontaneous model of superimposed preecla...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072460/ https://www.ncbi.nlm.nih.gov/pubmed/32075042 http://dx.doi.org/10.3390/biom10020302 |
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author | Terstappen, Fieke Clarke, Sinéad M. Joles, Jaap A. Ross, Courtney A Garrett, Michael R. Minnion, Magdalena Feelisch, Martin van Goor, Harry Sasser, Jennifer M. Lely, A. Titia |
author_facet | Terstappen, Fieke Clarke, Sinéad M. Joles, Jaap A. Ross, Courtney A Garrett, Michael R. Minnion, Magdalena Feelisch, Martin van Goor, Harry Sasser, Jennifer M. Lely, A. Titia |
author_sort | Terstappen, Fieke |
collection | PubMed |
description | Aberrant production of hydrogen sulfide (H(2)S) has been linked to preeclampsia. We hypothesized that sodium thiosulfate (STS), a H(2)S donor, reduces hypertension and proteinuria, and diminishes fetal growth restriction in the Dahl salt-sensitive (S) rat, a spontaneous model of superimposed preeclampsia. In addition to a control group (n = 13), two groups received STS via drinking water at a dose of 2 g (n = 9) or 3 g per kg body weight per day (n = 8) from gestational day (GD) 10 to 20. Uterine artery resistance index was measured (GD18), urinary protein excretion rate was determined (GD19), and blood pressure and fetal outcomes were evaluated (GD20). At 2 g, STS had no effect on preeclamptic symptoms or fetal outcome. At 3 g, STS reduced maternal hypertension (121.8 ± 3.0 vs. 136.3 ± 2.9), but increased proteinuria (89 ± 15 vs. 56 ± 5 mg/24 h), and relative kidney weight (0.86 ± 0.04 vs. 0.73 ± 0.02%). Fetal/placental weight ratio was reduced (3.83 ± 0.07 vs. 4.31 ± 0.08) without affecting litter size. No differences in uterine artery flow or renal histological damage were noted across treatment groups. While these data suggest a promising antihypertensive effect that could imply prolongation of preeclamptic pregnancies, the unfavorable effects on proteinuria, kidney weight, and fetal/placental weight ratio implies that clinical implementation of STS is contra-indicated until safety for mother and child can be verified. |
format | Online Article Text |
id | pubmed-7072460 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70724602020-03-19 Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia Terstappen, Fieke Clarke, Sinéad M. Joles, Jaap A. Ross, Courtney A Garrett, Michael R. Minnion, Magdalena Feelisch, Martin van Goor, Harry Sasser, Jennifer M. Lely, A. Titia Biomolecules Article Aberrant production of hydrogen sulfide (H(2)S) has been linked to preeclampsia. We hypothesized that sodium thiosulfate (STS), a H(2)S donor, reduces hypertension and proteinuria, and diminishes fetal growth restriction in the Dahl salt-sensitive (S) rat, a spontaneous model of superimposed preeclampsia. In addition to a control group (n = 13), two groups received STS via drinking water at a dose of 2 g (n = 9) or 3 g per kg body weight per day (n = 8) from gestational day (GD) 10 to 20. Uterine artery resistance index was measured (GD18), urinary protein excretion rate was determined (GD19), and blood pressure and fetal outcomes were evaluated (GD20). At 2 g, STS had no effect on preeclamptic symptoms or fetal outcome. At 3 g, STS reduced maternal hypertension (121.8 ± 3.0 vs. 136.3 ± 2.9), but increased proteinuria (89 ± 15 vs. 56 ± 5 mg/24 h), and relative kidney weight (0.86 ± 0.04 vs. 0.73 ± 0.02%). Fetal/placental weight ratio was reduced (3.83 ± 0.07 vs. 4.31 ± 0.08) without affecting litter size. No differences in uterine artery flow or renal histological damage were noted across treatment groups. While these data suggest a promising antihypertensive effect that could imply prolongation of preeclamptic pregnancies, the unfavorable effects on proteinuria, kidney weight, and fetal/placental weight ratio implies that clinical implementation of STS is contra-indicated until safety for mother and child can be verified. MDPI 2020-02-14 /pmc/articles/PMC7072460/ /pubmed/32075042 http://dx.doi.org/10.3390/biom10020302 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Terstappen, Fieke Clarke, Sinéad M. Joles, Jaap A. Ross, Courtney A Garrett, Michael R. Minnion, Magdalena Feelisch, Martin van Goor, Harry Sasser, Jennifer M. Lely, A. Titia Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title | Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title_full | Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title_fullStr | Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title_full_unstemmed | Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title_short | Sodium Thiosulfate in the Pregnant Dahl Salt-Sensitive Rat, a Model of Preeclampsia |
title_sort | sodium thiosulfate in the pregnant dahl salt-sensitive rat, a model of preeclampsia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072460/ https://www.ncbi.nlm.nih.gov/pubmed/32075042 http://dx.doi.org/10.3390/biom10020302 |
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