Combined Inhibition of Epigenetic Readers and Transcription Initiation Targets the EWS-ETS Transcriptional Program in Ewing Sarcoma

Background: Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the development of resistance. Here, we analyze the possible interaction of BRD4 with cyclin-dependent kinase (CDK) 9. Methods: Co-immu...

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Detalles Bibliográficos
Autores principales: H.S. Richter, Günther, Hensel, Tim, Schmidt, Oxana, Saratov, Vadim, von Heyking, Kristina, Becker-Dettling, Fiona, Prexler, Carolin, Yen, Hsi-Yu, Steiger, Katja, Fulda, Simone, Dirksen, Uta, Weichert, Wilko, Wang, Shudong, Burdach, Stefan, Schäfer, Beat W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072515/
https://www.ncbi.nlm.nih.gov/pubmed/32012890
http://dx.doi.org/10.3390/cancers12020304

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