Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines

Approximately 20% of multiple myeloma (MM) cases harbor a point mutation in KRAS. However, there is still no final consent on whether KRAS-mutations are associated with disease outcome. Specifically, no data exist on whether KRAS-mutations have an impact on survival of MM patients at diagnosis in th...

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Detalles Bibliográficos
Autores principales: Weißbach, Susann, Heredia-Guerrero, Sofia Catalina, Barnsteiner, Stefanie, Großhans, Lukas, Bodem, Jochen, Starz, Hanna, Langer, Christian, Appenzeller, Silke, Knop, Stefan, Steinbrunn, Torsten, Rost, Simone, Einsele, Hermann, Bargou, Ralf Christian, Rosenwald, Andreas, Stühmer, Thorsten, Leich, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072554/
https://www.ncbi.nlm.nih.gov/pubmed/32079091
http://dx.doi.org/10.3390/cancers12020455

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072554/
https://www.ncbi.nlm.nih.gov/pubmed/32079091
http://dx.doi.org/10.3390/cancers12020455

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