Cargando…

Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death

Elevated gene expression of Lymphocyte antigen 6K (LY6K) in cancer cells is associated with poor survival outcomes in multiple different cancer types including cervical, breast, ovarian, lung, and head and neck cancer. Since inhibition of LY6K expression inhibits cancer cell growth, we set out to ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benti, Senyi, Tiwari, Purushottam B., Goodlett, Dustin W., Daneshian, Leily, Kern, Grant B., Smith, Mark D., Uren, Aykut, Chruszcz, Maksymilian, Shimizu, Linda S., Upadhyay, Geeta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072568/ https://www.ncbi.nlm.nih.gov/pubmed/32098321 http://dx.doi.org/10.3390/cancers12020509

Ejemplares similares

Experimental and Computational Studies Reveal Novel Interaction of Lymphocytes Antigen 6K to TGF-β Receptor Complex
por: Andrys-Olek, Justyna, et al.
Publicado: (2023)

Investigating molecular interactions between oxidized neuroglobin and cytochrome c
por: Tiwari, Purushottam B., et al.
Publicado: (2018)

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels
por: Wang, Ze-Jun, et al.
Publicado: (2019)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Emerging Role of Lymphocyte Antigen-6 Family of Genes in Cancer and Immune Cells
por: Upadhyay, Geeta
Publicado: (2019)

Analysis of protein structures containing HEPES and MES molecules
por: Macnar, Joanna Magdalena, et al.
Publicado: (2022)

SPRD: a surface plasmon resonance database of common factors for better experimental planning
por: Tiwari, Purushottam B., et al.
Publicado: (2021)

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells
por: Jabbari, Esmaiel, et al.
Publicado: (2015)

(S)-(−)-6-(4-Bromophenyl)-2,3,5,6-tetrahydrothiazolo[2,3-b]imidazolium hydrogen oxalate
por: Minor, Thomas, et al.
Publicado: (2008)

RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1
por: Erkizan, Hayriye Verda, et al.
Publicado: (2015)

2,4-Dichlorobenzaldehyde
por: Cabello, Ricardo, et al.
Publicado: (2009)

Redetermination of 2-[4-(2-hydroxyethyl)piperazin-1-ium-1-yl]ethanesulfonate at 100 K
por: Sledz, Pawel, et al.
Publicado: (2009)

2,3-Difluorobenzoic acid
por: Knapik, Aleksandra A., et al.
Publicado: (2008)

Structural Aspects of the Allergen-Antibody Interaction
por: Pomés, Anna, et al.
Publicado: (2020)

Evaluation of the theoretical risk of cross‐reactivity among recently identified food allergens for dogs
por: Olivry, Thierry, et al.
Publicado: (2022)

A robust method for the estimation and visualization of IgE cross-reactivity likelihood between allergens belonging to the same protein family
por: Chruszcz, Maksymilian, et al.
Publicado: (2018)

Allergens and their associated small molecule ligands—their dual role in sensitization
por: Chruszcz, Maksymilian, et al.
Publicado: (2021)

Human Monoclonal IgE Antibodies—a Major Milestone in Allergy
por: Smith, Scott A., et al.
Publicado: (2022)

Structural Characterization of Act c 10.0101 and Pun g 1.0101—Allergens from the Non-Specific Lipid Transfer Protein Family
por: O’Malley, Andrea, et al.
Publicado: (2021)

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome
por: Luo, Linlin, et al.
Publicado: (2016)

The Lymphocyte Function–associated Antigen 1 I Domain Is a Transient Binding Module for Intercellular Adhesion Molecule (ICAM)-1 and ICAM-3 in Hydrodynamic Flow
por: Knorr, Ruth, et al.
Publicado: (1997)

Peanut panallergen Ara h 8 IgE and IgG4 epitopes
por: Hurlburt, Barry, et al.
Publicado: (2014)

Structural and functional insight into the universal stress protein family
por: Tkaczuk, Karolina L, et al.
Publicado: (2013)

Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity
por: Nakazawa, Kay, et al.
Publicado: (2023)

Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules
por: Glimcher, LH, et al.
Publicado: (1981)

Modulation of Susceptibility to HIV-1 Infection by the Cytotoxic T Lymphocyte Antigen 4 Costimulatory Molecule
por: Riley, James L., et al.
Publicado: (2000)

The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1
Publicado: (1991)

Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins
por: Handing, Katarzyna B., et al.
Publicado: (2016)

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1
por: Barber-Rotenberg, Julie S., et al.
Publicado: (2012)

IMMUNOGLOBULIN MOLECULES ON THE SURFACE OF ACTIVATED T LYMPHOCYTES IN THE RAT
por: Goldschneider, Irving, et al.
Publicado: (1973)

Synthesis and Structure–Activity Relationship Studies of Small Molecule Disruptors of EWS-FLI1 Interactions in Ewing’s Sarcoma
por: Tosso, Perrer N., et al.
Publicado: (2014)

Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis
por: Schlachter, Caleb R., et al.
Publicado: (2021)

Helix-A peptide prevents gp120-mediated neuronal loss
por: Avdoshina, Valeria, et al.
Publicado: (2019)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
por: Lin, Xionghao, et al.
Publicado: (2019)

Nonconventional (TL-encoded) major histocompatibility complex molecules present processed viral antigen to cytotoxic T lymphocytes
Publicado: (1991)

Antigen-specific T lymphocyte clones. III. Papain splits purified T suppressor molecules into two functional domains
Publicado: (1982)

Phosphorylation Regulates SIRT1 Function
por: Sasaki, Tsutomu, et al.
Publicado: (2008)

When the Frequencies of Sensitization and Elicitation of Allergic Reaction Do Not Correlate—The Case of Apple Gibberellin-Regulated Protein Tested in an Italian Population
por: Tuppo, Lisa, et al.
Publicado: (2021)

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue
Publicado: (1994)

Structural and Functional Characterization of the Hazelnut Allergen Cor a 8
por: Offermann, Lesa R., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_nnp6ijdoe9safr8a725nj2kses