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Mechanotransduction in T Cell Development, Differentiation and Function
Cells in the body are actively engaging with their environments that include both biochemical and biophysical aspects. The process by which cells convert mechanical stimuli from their environment to intracellular biochemical signals is known as mechanotransduction. Exemplifying the reliance on mecha...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072571/ https://www.ncbi.nlm.nih.gov/pubmed/32033255 http://dx.doi.org/10.3390/cells9020364 |
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author | Rushdi, Muaz Li, Kaitao Yuan, Zhou Travaglino, Stefano Grakoui, Arash Zhu, Cheng |
author_facet | Rushdi, Muaz Li, Kaitao Yuan, Zhou Travaglino, Stefano Grakoui, Arash Zhu, Cheng |
author_sort | Rushdi, Muaz |
collection | PubMed |
description | Cells in the body are actively engaging with their environments that include both biochemical and biophysical aspects. The process by which cells convert mechanical stimuli from their environment to intracellular biochemical signals is known as mechanotransduction. Exemplifying the reliance on mechanotransduction for their development, differentiation and function are T cells, which are central to adaptive immune responses. T cell mechanoimmunology is an emerging field that studies how T cells sense, respond and adapt to the mechanical cues that they encounter throughout their life cycle. Here we review different stages of the T cell’s life cycle where existing studies have shown important effects of mechanical force or matrix stiffness on a T cell as sensed through its surface molecules, including modulating receptor–ligand interactions, inducing protein conformational changes, triggering signal transduction, amplifying antigen discrimination and ensuring directed targeted cell killing. We suggest that including mechanical considerations in the immunological studies of T cells would inform a more holistic understanding of their development, differentiation and function. |
format | Online Article Text |
id | pubmed-7072571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70725712020-03-19 Mechanotransduction in T Cell Development, Differentiation and Function Rushdi, Muaz Li, Kaitao Yuan, Zhou Travaglino, Stefano Grakoui, Arash Zhu, Cheng Cells Review Cells in the body are actively engaging with their environments that include both biochemical and biophysical aspects. The process by which cells convert mechanical stimuli from their environment to intracellular biochemical signals is known as mechanotransduction. Exemplifying the reliance on mechanotransduction for their development, differentiation and function are T cells, which are central to adaptive immune responses. T cell mechanoimmunology is an emerging field that studies how T cells sense, respond and adapt to the mechanical cues that they encounter throughout their life cycle. Here we review different stages of the T cell’s life cycle where existing studies have shown important effects of mechanical force or matrix stiffness on a T cell as sensed through its surface molecules, including modulating receptor–ligand interactions, inducing protein conformational changes, triggering signal transduction, amplifying antigen discrimination and ensuring directed targeted cell killing. We suggest that including mechanical considerations in the immunological studies of T cells would inform a more holistic understanding of their development, differentiation and function. MDPI 2020-02-05 /pmc/articles/PMC7072571/ /pubmed/32033255 http://dx.doi.org/10.3390/cells9020364 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rushdi, Muaz Li, Kaitao Yuan, Zhou Travaglino, Stefano Grakoui, Arash Zhu, Cheng Mechanotransduction in T Cell Development, Differentiation and Function |
title | Mechanotransduction in T Cell Development, Differentiation and Function |
title_full | Mechanotransduction in T Cell Development, Differentiation and Function |
title_fullStr | Mechanotransduction in T Cell Development, Differentiation and Function |
title_full_unstemmed | Mechanotransduction in T Cell Development, Differentiation and Function |
title_short | Mechanotransduction in T Cell Development, Differentiation and Function |
title_sort | mechanotransduction in t cell development, differentiation and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072571/ https://www.ncbi.nlm.nih.gov/pubmed/32033255 http://dx.doi.org/10.3390/cells9020364 |
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