Cargando…

A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes

The ubiquitin-editing protein A20 (TNFAIP3) is a known key player in the regulation of immune responses in many organs. Genome-wide associated studies (GWASs) have linked A20 with a number of inflammatory and autoimmune disorders, including psoriasis. Here, we identified a previously unrecognized ro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feoktistova, Maria, Makarov, Roman, Brenji, Sihem, Schneider, Anne T., Hooiveld, Guido J., Luedde, Tom, Leverkus, Martin, Yazdi, Amir S., Panayotova-Dimitrova, Diana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072579/ https://www.ncbi.nlm.nih.gov/pubmed/32028675 http://dx.doi.org/10.3390/cells9020351

Ejemplares similares

RIPK1 and TRADD Regulate TNF-Induced Signaling and Ripoptosome Formation
por: Feoktistova, Maria, et al.
Publicado: (2021)

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms
por: Feoktistova, Maria, et al.
Publicado: (2011)

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP
por: Feoktistova, Maria, et al.
Publicado: (2020)

ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly
por: Selmi, Tommaso, et al.
Publicado: (2015)

Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK
por: Zarnegar, Brian J., et al.
Publicado: (2008)

Molecular determinants of Smac mimetic induced degradation of cIAP1 and cIAP2
por: Darding, M, et al.
Publicado: (2011)

LCL161 increases paclitaxel-induced apoptosis by degrading cIAP1 and cIAP2 in NSCLC
por: Yang, Chengcheng, et al.
Publicado: (2016)

Cytoplasmic and Nuclear Functions of cIAP1
por: Zadoroznyj, Aymeric, et al.
Publicado: (2022)

Pitfalls in the Application of Dispase-Based Keratinocyte Dissociation Assay for In Vitro Analysis of Pemphigus Vulgaris
por: Schmidt, Morna F., et al.
Publicado: (2022)

Bivalent IAP antagonists inhibit TRAF2-bound cIAPs and limit TNF-mediated NF-κB signaling
por: Condon, Stephen M
Publicado: (2016)

Effects of cIAP-1, cIAP-2 and XIAP triple knockdown on prostate cancer cell susceptibility to apoptosis, cell survival and proliferation
por: Gill, Catherine, et al.
Publicado: (2009)

Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization
por: Morón-Calvente, Virginia, et al.
Publicado: (2018)

Expression and Correlation of Cell-Free cIAP-1 and cIAP-2 mRNA in Breast Cancer Patients: A Study from India
por: Verma, Amit Kumar, et al.
Publicado: (2020)

Bivalent IAP antagonists, but not monovalent IAP antagonists, inhibit TNF-mediated NF-κB signaling by degrading TRAF2-associated cIAP1 in cancer cells
por: Mitsuuchi, Y, et al.
Publicado: (2017)

E2F1 binds to the peptide-binding groove within the BIR3 domain of cIAP1 and requires cIAP1 for chromatin binding
por: Allègre, Jennifer, et al.
Publicado: (2018)

Role of A20 in cIAP-2 Protection against Tumor Necrosis Factor α (TNF-α)-Mediated Apoptosis in Endothelial Cells
por: Guo, Shuzhen, et al.
Publicado: (2014)

Rb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiency
por: Cheng, Le, et al.
Publicado: (2010)

cIAP-1 Controls Innate Immunity to C. pneumoniae Pulmonary Infection
por: Prakash, Hridayesh, et al.
Publicado: (2009)

cIAP1/2 inhibition synergizes with TNF inhibition in autoimmunity by down-regulating IL-17A and inducing T(regs)
por: Kawalkowska, Joanna Z., et al.
Publicado: (2019)

cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer in vitro
por: Su, Wei, et al.
Publicado: (2019)

TRIM56 promotes malignant progression of glioblastoma by stabilizing cIAP1 protein
por: Yang, Xu, et al.
Publicado: (2022)

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1–TRAF2 complex to sensitize tumor cells to TNFα
por: Vince, James E., et al.
Publicado: (2008)

TAK1 kinase determines TRAIL sensitivity by modulating reactive oxygen species and cIAP
por: Morioka, Sho, et al.
Publicado: (2009)

HAX1 regulates E3 ubiquitin ligase activity of cIAPs by promoting their dimerization
por: Choi, Jin Sun, et al.
Publicado: (2014)

PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1
por: Guo, Haihong, et al.
Publicado: (2019)

Correction: cIAP1 promotes proliferation and migration and prevents apoptosis in gallbladder cancer in vitro
Publicado: (2019)

USP11: A key regulator of cIAP2 stability and sensitivity to SMAC mimetics
por: Lee, Eun-Woo, et al.
Publicado: (2015)

cIAP1/2 are involved in the radiosensitizing effect of birinapant on NSCLC cell line in vitro
por: Sun, Hao, et al.
Publicado: (2021)

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression
por: Paschall, Amy V, et al.
Publicado: (2014)

Synergistic anticancer effect of cisplatin and Chal-24 combination through IAP and c-FLIP(L) degradation, Ripoptosome formation and autophagy-mediated apoptosis
por: Shi, Shaoqing, et al.
Publicado: (2015)

cIAP1 regulates the EGFR/Snai2 axis in triple-negative breast cancer cells
por: Majorini, Maria Teresa, et al.
Publicado: (2018)

cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF‐κB pathway
por: Jiang, Xiaojie, et al.
Publicado: (2017)

RETRACTED ARTICLE: Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
por: La, V., et al.
Publicado: (2017)

TWEAK Promotes the Proliferation of Squamous Cell Carcinoma Cells Through Activating cIAP1 Signals
por: Liang, Lili, et al.
Publicado: (2020)

Retraction Note: Birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
por: La, V., et al.
Publicado: (2021)

Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis
por: Biswas, Debolina D., et al.
Publicado: (2022)

cIAPs control RIPK1 kinase activity‐dependent and ‐independent cell death and tissue inflammation
por: Schorn, Fabian, et al.
Publicado: (2023)

RANKL enhances the effect of an antagonist of inhibitor of apoptosis proteins (cIAPs) in RANK-positive breast cancer cells
por: Casimiro, S., et al.
Publicado: (2013)

Increased resistance to proteasome inhibitors in multiple myeloma mediated by cIAP2 - implications for a combinatorial treatment
por: Duvefelt, Charlotte Fristedt, et al.
Publicado: (2015)

Editorial Expression of Concern: birinapant sensitizes platinum-resistant carcinomas with high levels of cIAP to carboplatin therapy
por: La, V., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1ppopdfn06h13lcmgfs4sptudg