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Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells

Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a...

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Autores principales: Prabhu, Kirti S., Raza, Afsheen, Karedath, Thasni, Raza, Syed Shadab, Fathima, Hamna, Ahmed, Eiman I., Kuttikrishnan, Shilpa, Therachiyil, Lubna, Kulinski, Michal, Dermime, Said, Junejo, Kulsoom, Steinhoff, Martin, Uddin, Shahab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072613/
https://www.ncbi.nlm.nih.gov/pubmed/32033146
http://dx.doi.org/10.3390/cancers12020351
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author Prabhu, Kirti S.
Raza, Afsheen
Karedath, Thasni
Raza, Syed Shadab
Fathima, Hamna
Ahmed, Eiman I.
Kuttikrishnan, Shilpa
Therachiyil, Lubna
Kulinski, Michal
Dermime, Said
Junejo, Kulsoom
Steinhoff, Martin
Uddin, Shahab
author_facet Prabhu, Kirti S.
Raza, Afsheen
Karedath, Thasni
Raza, Syed Shadab
Fathima, Hamna
Ahmed, Eiman I.
Kuttikrishnan, Shilpa
Therachiyil, Lubna
Kulinski, Michal
Dermime, Said
Junejo, Kulsoom
Steinhoff, Martin
Uddin, Shahab
author_sort Prabhu, Kirti S.
collection PubMed
description Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a product generated from erroneous transcription. Even though understanding of biological and molecular functions of noncoding RNA remains enigmatic, researchers have established the pivotal role of these RNAs in governing a plethora of biological phenomena that includes cancer-associated cellular processes such as proliferation, invasion, migration, apoptosis, and stemness. In addition to this, the transmission of microRNAs and long non-coding RNAs was identified as a source of communication to breast cancer cells either locally or systemically. The present review provides in-depth information with an aim at discovering the fundamental potential of non-coding RNAs, by providing knowledge of biogenesis and functional roles of micro RNA and long non-coding RNAs in breast cancer and breast cancer stem cells, as either oncogenic drivers or tumor suppressors. Furthermore, non-coding RNAs and their potential role as diagnostic and therapeutic moieties have also been summarized.
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spelling pubmed-70726132020-03-19 Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells Prabhu, Kirti S. Raza, Afsheen Karedath, Thasni Raza, Syed Shadab Fathima, Hamna Ahmed, Eiman I. Kuttikrishnan, Shilpa Therachiyil, Lubna Kulinski, Michal Dermime, Said Junejo, Kulsoom Steinhoff, Martin Uddin, Shahab Cancers (Basel) Review Breast cancer is regarded as a heterogeneous and complicated disease that remains the prime focus in the domain of public health concern. Next-generation sequencing technologies provided a new perspective dimension to non-coding RNAs, which were initially considered to be transcriptional noise or a product generated from erroneous transcription. Even though understanding of biological and molecular functions of noncoding RNA remains enigmatic, researchers have established the pivotal role of these RNAs in governing a plethora of biological phenomena that includes cancer-associated cellular processes such as proliferation, invasion, migration, apoptosis, and stemness. In addition to this, the transmission of microRNAs and long non-coding RNAs was identified as a source of communication to breast cancer cells either locally or systemically. The present review provides in-depth information with an aim at discovering the fundamental potential of non-coding RNAs, by providing knowledge of biogenesis and functional roles of micro RNA and long non-coding RNAs in breast cancer and breast cancer stem cells, as either oncogenic drivers or tumor suppressors. Furthermore, non-coding RNAs and their potential role as diagnostic and therapeutic moieties have also been summarized. MDPI 2020-02-04 /pmc/articles/PMC7072613/ /pubmed/32033146 http://dx.doi.org/10.3390/cancers12020351 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Prabhu, Kirti S.
Raza, Afsheen
Karedath, Thasni
Raza, Syed Shadab
Fathima, Hamna
Ahmed, Eiman I.
Kuttikrishnan, Shilpa
Therachiyil, Lubna
Kulinski, Michal
Dermime, Said
Junejo, Kulsoom
Steinhoff, Martin
Uddin, Shahab
Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title_full Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title_fullStr Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title_full_unstemmed Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title_short Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells
title_sort non-coding rnas as regulators and markers for targeting of breast cancer and cancer stem cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072613/
https://www.ncbi.nlm.nih.gov/pubmed/32033146
http://dx.doi.org/10.3390/cancers12020351
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