Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability

Conflicts between replication and transcription are a common source of genomic instability, a characteristic of almost all human cancers. Aberrant R-loops can cause a block to replication fork progression. A growing number of factors are involved in the resolution of these harmful structures and man...

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Detalles Bibliográficos
Autores principales: Marabitti, Veronica, Lillo, Giorgia, Malacaria, Eva, Palermo, Valentina, Pichierri, Pietro, Franchitto, Annapaola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072626/
https://www.ncbi.nlm.nih.gov/pubmed/32046194
http://dx.doi.org/10.3390/cancers12020389

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072626/
https://www.ncbi.nlm.nih.gov/pubmed/32046194
http://dx.doi.org/10.3390/cancers12020389

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