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Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability
Conflicts between replication and transcription are a common source of genomic instability, a characteristic of almost all human cancers. Aberrant R-loops can cause a block to replication fork progression. A growing number of factors are involved in the resolution of these harmful structures and man...
Autores principales: | Marabitti, Veronica, Lillo, Giorgia, Malacaria, Eva, Palermo, Valentina, Pichierri, Pietro, Franchitto, Annapaola |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072626/ https://www.ncbi.nlm.nih.gov/pubmed/32046194 http://dx.doi.org/10.3390/cancers12020389 |
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