Cargando…

RAD52: Viral Friend or Foe?

Mammalian Radiation Sensitive 52 (RAD52) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic...

Descripción completa

Detalles Bibliográficos
Autor principal: Hendrickson, Eric A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072633/
https://www.ncbi.nlm.nih.gov/pubmed/32046320
http://dx.doi.org/10.3390/cancers12020399
_version_ 1783506451966197760
author Hendrickson, Eric A.
author_facet Hendrickson, Eric A.
author_sort Hendrickson, Eric A.
collection PubMed
description Mammalian Radiation Sensitive 52 (RAD52) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR), a mechanism that can be used to re-start broken replication forks and to elongate the ends of chromosomes in telomerase-negative cells. Viruses have historically evolved a myriad of mechanisms in which they either conscript cellular factors or, more frequently, inactivate them as a means to enable their own replication and survival. Recent data suggests that Adeno-Associated Virus (AAV) may replicate its DNA in a BIR-like fashion and/or utilize RAD52 to facilitate viral transduction and, as such, likely conscripts/requires the host RAD52 protein to promote its perpetuation.
format Online
Article
Text
id pubmed-7072633
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70726332020-03-19 RAD52: Viral Friend or Foe? Hendrickson, Eric A. Cancers (Basel) Review Mammalian Radiation Sensitive 52 (RAD52) is a gene whose scientific reputation has recently seen a strong resurgence. In the past decade, RAD52, which was thought to be dispensable for most DNA repair and recombination reactions in mammals, has been shown to be important for a bevy of DNA metabolic pathways. One of these processes is termed break-induced replication (BIR), a mechanism that can be used to re-start broken replication forks and to elongate the ends of chromosomes in telomerase-negative cells. Viruses have historically evolved a myriad of mechanisms in which they either conscript cellular factors or, more frequently, inactivate them as a means to enable their own replication and survival. Recent data suggests that Adeno-Associated Virus (AAV) may replicate its DNA in a BIR-like fashion and/or utilize RAD52 to facilitate viral transduction and, as such, likely conscripts/requires the host RAD52 protein to promote its perpetuation. MDPI 2020-02-08 /pmc/articles/PMC7072633/ /pubmed/32046320 http://dx.doi.org/10.3390/cancers12020399 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hendrickson, Eric A.
RAD52: Viral Friend or Foe?
title RAD52: Viral Friend or Foe?
title_full RAD52: Viral Friend or Foe?
title_fullStr RAD52: Viral Friend or Foe?
title_full_unstemmed RAD52: Viral Friend or Foe?
title_short RAD52: Viral Friend or Foe?
title_sort rad52: viral friend or foe?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072633/
https://www.ncbi.nlm.nih.gov/pubmed/32046320
http://dx.doi.org/10.3390/cancers12020399
work_keys_str_mv AT hendricksonerica rad52viralfriendorfoe