Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors

Phosphodiesterases (PDEs) form a superfamily of enzymes that catalyze the hydrolysis of cyclic nucleotides adenosine 3′5′-cyclic monophosphate (cAMP) and guanosine 3′5′-cyclic monophosphate (cGMP) to their inactive 5′ monophosphates. cAMP plays a critical role as a second messenger in endocrine tiss...

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Detalles Bibliográficos
Autores principales: Pinto, Emilia Modolo, Faucz, Fabio R., Paza, Luana Z., Wu, Gang, Fernandes, Elizabeth S., Bertherat, Jerome, Stratakis, Constantine A., Lalli, Enzo, Ribeiro, Raul C., Rodriguez-Galindo, Carlos, Figueiredo, Bonald C., Zambetti, Gerard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072638/
https://www.ncbi.nlm.nih.gov/pubmed/32098292
http://dx.doi.org/10.3390/cancers12020506

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