Reactivation of VX-Inhibited Human Acetylcholinesterase by Deprotonated Pralidoxime. A Complementary Quantum Mechanical Study

In the present work, we performed a complementary quantum mechanical (QM) study to describe the mechanism by which deprotonated pralidoxime (2-PAM) could reactivate human (Homo sapiens sapiens) acetylcholinesterase (HssAChE) inhibited by the nerve agent VX. Such a reaction is proposed to occur in su...

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Detalles Bibliográficos
Autores principales: da Silva, Jorge Alberto Valle, Pereira, Ander Francisco, LaPlante, Steven R., Kuca, Kamil, Ramalho, Teodorico Castro, França, Tanos Celmar Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072650/
https://www.ncbi.nlm.nih.gov/pubmed/32012780
http://dx.doi.org/10.3390/biom10020192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072650/
https://www.ncbi.nlm.nih.gov/pubmed/32012780
http://dx.doi.org/10.3390/biom10020192

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