Cargando…

Trabecular Bone Deficit and Enhanced Anabolic Response to Re-Ambulation after Disuse in Perlecan-Deficient Skeleton

Perlecan/Hspg2, a large monomeric heparan sulfate proteoglycan, is found in the basement membrane and extracellular matrix, where it acts as a matrix scaffold, growth factor depot, and tissue barrier. Perlecan deficiency leads to skeletal dysplasia in Schwartz-Jampel Syndrome (SJS) and is a risk fac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parajuli, Ashutosh, Pei, Shaopeng, Zhao, Hongbo, Martinez, Jerahme R., Lu, X. Lucas, Liu, X. Sherry, Farach-Carson, Mary C., Kirn-Safran, Catherine B., Wang, Liyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072656/ https://www.ncbi.nlm.nih.gov/pubmed/32013135 http://dx.doi.org/10.3390/biom10020198

Ejemplares similares

Osteocytic Pericellular Matrix (PCM): Accelerated Degradation under In Vivo Loading and Unloading Conditions Using a Novel Imaging Approach
por: Pei, Shaopeng, et al.
Publicado: (2021)

Modular Proteoglycan Perlecan/HSPG2: Mutations, Phenotypes, and Functions
por: Martinez, Jerahme R., et al.
Publicado: (2018)

Evolution of the Perlecan/HSPG2 Gene and Its Activation in Regenerating Nematostella vectensis
por: Warren, Curtis R., et al.
Publicado: (2015)

Perlecan/Hspg2 Deficiency Alters the Pericellular Space of the Lacunocanalicular System Surrounding Osteocytic Processes in Cortical Bone
por: Thompson, William R, et al.
Publicado: (2011)

Expression of the Heparan Sulfate Proteoglycan, Perlecan, during Mouse Embryogenesis and Perlecan Chondrogenic Activity In Vitro
por: French, M.M., et al.
Publicado: (1999)

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells
por: Grindel, Brian J., et al.
Publicado: (2018)

Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients
por: Grindel, Brian, et al.
Publicado: (2016)

Correction: Perlecan/HSPG2 and matrilysin/MMP-7 as indices of tissue invasion: tissue localization and circulating perlecan fragments in a cohort of 288 radical prostatectomy patients
por: Grindel, Brian, et al.
Publicado: (2016)

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals
por: Segalés, Jessica, et al.
Publicado: (2020)

Anabolic effects of IGF-1 signaling on the skeleton
por: Tahimic, Candice G. T., et al.
Publicado: (2013)

Prolonging disuse in aged mice amplifies cortical but not trabecular bones’ response to mechanical loading
por: Souza, R. De, et al.
Publicado: (2017)

SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models
por: Brasil da Costa, Fabio Henrique, et al.
Publicado: (2020)

Limited Trabecular Bone Density Heterogeneity in the Human Skeleton
por: Chirchir, Habiba
Publicado: (2016)

Cleavage of the Perlecan-Semaphorin 3A-Plexin A1-Neuropilin-1 (PSPN) Complex by Matrix Metalloproteinase 7/Matrilysin Triggers Prostate Cancer Cell Dyscohesion and Migration
por: Tellman, Tristen V., et al.
Publicado: (2021)

Acetylcholinesterase Clustering at the Neuromuscular Junction Involves Perlecan and Dystroglycan
por: Peng, H. Benjamin, et al.
Publicado: (1999)

Perlecan, a candidate gene for the CAPB locus, regulates prostate cancer cell growth via the Sonic Hedgehog pathway
por: Datta, Milton W, et al.
Publicado: (2006)

Inhibition of T-Type Voltage Sensitive Calcium Channel Reduces Load-Induced OA in Mice and Suppresses the Catabolic Effect of Bone Mechanical Stress on Chondrocytes
por: Srinivasan, Padma P., et al.
Publicado: (2015)

Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration
por: Chiu, Yu-Chieh, et al.
Publicado: (2016)

Perlecan controls neurogenesis in the developing telencephalon
por: Girós, Amparo, et al.
Publicado: (2007)

Nutritional Strategies to Offset Disuse-Induced Skeletal Muscle Atrophy and Anabolic Resistance in Older Adults: From Whole-Foods to Isolated Ingredients
por: Marshall, Ryan N., et al.
Publicado: (2020)

Missense Mutations in LRP5 Associated with High Bone Mass Protect the Mouse Skeleton from Disuse- and Ovariectomy-Induced Osteopenia
por: Niziolek, Paul J., et al.
Publicado: (2015)

Life without Perlecan Has Its Problems
por: Olsen, Bjorn R.
Publicado: (1999)

Perlecan and the Blood-Brain Barrier: Beneficial Proteolysis?
por: Roberts, Jill, et al.
Publicado: (2012)

Perlecan and synaptophysin changes in denervated skeletal muscle☆
por: Ma, Kai, et al.
Publicado: (2012)

Increased Risk of Aortic Dissection with Perlecan Deficiency
por: Nonaka, Risa, et al.
Publicado: (2021)

Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1
por: Ellis, April L, et al.
Publicado: (2010)

Gabapentin Disrupts Binding of Perlecan to the α(2)δ(1) Voltage Sensitive Calcium Channel Subunit and Impairs Skeletal Mechanosensation
por: Reyes Fernandez, Perla C., et al.
Publicado: (2022)

Effect of electrical stimulation-induced muscle force and streptomycin treatment on muscle and trabecular bone mass in early-stage disuse musculoskeletal atrophy
por: Tamaki, H., et al.
Publicado: (2015)

Perlecan Maintains the Integrity of Cartilage and Some Basement Membranes
por: Costell, Mercedes, et al.
Publicado: (1999)

Disuse TWEAKs muscle loss
por: Short, Ben
Publicado: (2010)

Disuse Post-Traumatic Decalcification
Publicado: (1936)

Substance 'disuse' during crisis
por: Shetty, S. S., et al.
Publicado: (2020)

A central function for perlecan in skeletal muscle and cardiovascular development
por: Zoeller, Jason J., et al.
Publicado: (2008)

Perlecan Maintains Microvessel Integrity In Vivo and Modulates Their Formation In Vitro
por: Gustafsson, Erika, et al.
Publicado: (2013)

Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction
por: Kamimura, Keisuke, et al.
Publicado: (2013)

Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia
por: Trout, Amanda L., et al.
Publicado: (2020)

Perlecan: a review of its role in neurologic and musculoskeletal disease
por: Lavorgna, Tessa R., et al.
Publicado: (2023)

Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment
por: Petrocelli, Jonathan J., et al.
Publicado: (2023)

Mitochondrial dysregulation and muscle disuse atrophy
por: Ji, Li Li, et al.
Publicado: (2019)

Disuse Osteoporosis: Clinical and Mechanistic Insights
por: Rolvien, Tim, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_mgfmarakukt5lpdjjndjgjb8ls