A ”Clickable” Probe for Active MGMT in Glioblastoma Demonstrates Two Discrete Populations of MGMT

Various pathways can repair DNA alkylation by chemotherapeutic agents such as temozolomide (TMZ). The enzyme O(6)-methylguanine methyltransferase (MGMT) removes O(6)-methylated DNA adducts, leading to the failure of chemotherapy in resistant glioblastomas. Because of the anti-chemotherapeutic activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Raghavan, Sudhir, Baskin, David S., Sharpe, Martyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072665/
https://www.ncbi.nlm.nih.gov/pubmed/32075134
http://dx.doi.org/10.3390/cancers12020453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072665/
https://www.ncbi.nlm.nih.gov/pubmed/32075134
http://dx.doi.org/10.3390/cancers12020453

Ejemplares similares