Cargando…

Arachidonoylcholine and Other Unsaturated Long-Chain Acylcholines Are Endogenous Modulators of the Acetylcholine Signaling System

Cholines acylated with unsaturated fatty acids are a recently discovered family of endogenous lipids. However, the data on the biological activity of acylcholines remain very limited. We hypothesized that acylcholines containing residues of arachidonic (AA-CHOL), oleic (Ol-CHOL), linoleic (Ln-CHOL),...

Descripción completa

Detalles Bibliográficos
Autores principales:	Akimov, Mikhail G., Kudryavtsev, Denis S., Kryukova, Elena V., Fomina-Ageeva, Elena V., Zakharov, Stanislav S., Gretskaya, Natalia M., Zinchenko, Galina N., Serkov, Igor V., Makhaeva, Galina F., Boltneva, Natalia P., Kovaleva, Nadezhda V., Serebryakova, Olga G., Lushchekina, Sofya V., Palikov, Victor A., Palikova, Yulia, Dyachenko, Igor A., Kasheverov, Igor E., Tsetlin, Victor I., Bezuglov, Vladimir V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072677/ https://www.ncbi.nlm.nih.gov/pubmed/32059521 http://dx.doi.org/10.3390/biom10020283

Ejemplares similares

New Hybrids of 4-Amino-2,3-polymethylene-quinoline and p-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer’s Disease Treatment
por: Makhaeva, Galina F., et al.
Publicado: (2020)

In Vivo Targeted Metabolomic Profiling of Prostanit, a Novel Anti-PAD NO-Donating Alprostadil-Based Drug
por: Shestakova, Ksenia M., et al.
Publicado: (2020)

Bis-Amiridines as Acetylcholinesterase and Butyrylcholinesterase Inhibitors: N-Functionalization Determines the Multitarget Anti-Alzheimer’s Activity Profile
por: Makhaeva, Galina F., et al.
Publicado: (2022)

New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment
por: Makhaeva, Galina F., et al.
Publicado: (2020)

Conjugates of Tacrine with Salicylamide as Promising Multitarget Agents for Alzheimer's Disease
por: Grishchenko, Maria V., et al.
Publicado: (2022)

Orthosteric and/or Allosteric Binding of α-Conotoxins to Nicotinic Acetylcholine Receptors and Their Models
por: Kryukova, Elena V., et al.
Publicado: (2018)

Multicomponent Lipid Nanoparticles for RNA Transfection
por: Gretskaya, Nataliya, et al.
Publicado: (2023)

Marine Natural Products Acting on the Acetylcholine-Binding Protein and Nicotinic Receptors: From Computer Modeling to Binding Studies and Electrophysiology
por: Kudryavtsev, Denis, et al.
Publicado: (2014)

Analogs of 6-Bromohypaphorine with Increased Agonist Potency for α7 Nicotinic Receptor as Anti-Inflammatory Analgesic Agents
por: Ivanov, Igor A., et al.
Publicado: (2023)

Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease
por: Makhaeva, Galina F., et al.
Publicado: (2015)

The Mechanisms of GPR55 Receptor Functional Selectivity during Apoptosis and Proliferation Regulation in Cancer Cells
por: Akimov, Mikhail G., et al.
Publicado: (2023)

Novel Three-Finger Neurotoxins from Naja melanoleuca Cobra Venom Interact with GABA(A) and Nicotinic Acetylcholine Receptors
por: Son, Lina, et al.
Publicado: (2021)

Spatial Structure and Activity of Synthetic Fragments of Lynx1 and of Nicotinic Receptor Loop C Models
por: Mineev, Konstantin S., et al.
Publicado: (2020)

From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs
por: Kryukova, Elena V., et al.
Publicado: (2019)

Conjugates of Tacrine and Salicylic Acid Derivatives as New Promising Multitarget Agents for Alzheimer’s Disease
por: Makhaeva, Galina F., et al.
Publicado: (2023)

Synthesis of 4-Aminopyrazol-5-ols as Edaravone Analogs and Their Antioxidant Activity
por: Burgart, Yanina V., et al.
Publicado: (2022)

Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
por: Bachurin, Sergey O., et al.
Publicado: (2019)

Pancreatic and snake venom presynaptically active phospholipases A(2) inhibit nicotinic acetylcholine receptors
por: Vulfius, Catherine A., et al.
Publicado: (2017)

New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones
por: Elkina, Natalia A., et al.
Publicado: (2022)

Anti-Inflammatory and Analgesic Effects of TRPV1 Polypeptide Modulator APHC3 in Models of Osteo- and Rheumatoid Arthritis
por: Logashina, Yulia A., et al.
Publicado: (2021)

Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide
por: Kudryavtsev, Denis S., et al.
Publicado: (2020)

Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites
por: Kudryavtsev, Denis S., et al.
Publicado: (2018)

Powerful Potential of Polyfluoroalkyl-Containing 4-Arylhydrazinylidenepyrazol-3-ones for Pharmaceuticals
por: Burgart, Yanina V., et al.
Publicado: (2022)

ACTH(6–9)PGP Peptide Protects SH-SY5Y Cells from H(2)O(2), tert-Butyl Hydroperoxide, and Cyanide Cytotoxicity via Stimulation of Proliferation and Induction of Prosurvival-Related Genes
por: Akimov, Mikhail G., et al.
Publicado: (2021)

Antiviral Effects of Animal Toxins: Is There a Way to Drugs?
por: Utkin, Yuri, et al.
Publicado: (2022)

Fifty Years of Animal Toxin Research at the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry RAS
por: Tsetlin, Victor, et al.
Publicado: (2023)

Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease
por: Makhaeva, Galina F., et al.
Publicado: (2023)

TRPV1 Blocker HCRG21 Suppresses TNF-α Production and Prevents the Development of Edema and Hypersensitivity in Carrageenan-Induced Acute Local Inflammation
por: Sintsova, Oksana, et al.
Publicado: (2021)

GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation
por: Akimov, Mikhail G., et al.
Publicado: (2021)

Analysis of nociceptive effects of neurotoxic phospholipase A2 from Vipera nikolskii venom in mice
por: Dyachenko, Igor A, et al.
Publicado: (2013)

A New Method for the Visualization of Living Dopaminergic Neurons and Prospects for Using It to Develop Targeted Drug Delivery to These Cells
por: Blokhin, Victor, et al.
Publicado: (2022)

Conjugation of Aminoadamantane and γ-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands
por: Bachurin, Sergey O., et al.
Publicado: (2021)

Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms
por: Tsetlin, Victor, et al.
Publicado: (2021)

Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties
por: Osmakov, Dmitry I., et al.
Publicado: (2019)

Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
por: Bachurin, Sergey O., et al.
Publicado: (2017)

Conjugates of Methylene Blue with Cycloalkaneindoles as New Multifunctional Agents for Potential Treatment of Neurodegenerative Disease
por: Bachurin, Sergey O., et al.
Publicado: (2022)

Azemiopsin from Azemiops feae Viper Venom, a Novel Polypeptide Ligand of Nicotinic Acetylcholine Receptor
por: Utkin, Yuri N., et al.
Publicado: (2012)

Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
por: Kasheverov, Igor E., et al.
Publicado: (2011)

Marine Origin Ligands of Nicotinic Receptors: Low Molecular Compounds, Peptides and Proteins for Fundamental Research and Practical Applications
por: Kasheverov, Igor, et al.
Publicado: (2022)

α7- and α9-Containing Nicotinic Acetylcholine Receptors in the Functioning of Immune System and in Pain
por: Shelukhina, Irina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_hou4fe0aqj529f7j9o2lgsh1mr