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GP130 Cytokines in Breast Cancer and Bone

Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which...

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Detalles Bibliográficos
Autores principales: Omokehinde, Tolu, Johnson, Rachelle W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072680/
https://www.ncbi.nlm.nih.gov/pubmed/32023849
http://dx.doi.org/10.3390/cancers12020326
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author Omokehinde, Tolu
Johnson, Rachelle W.
author_facet Omokehinde, Tolu
Johnson, Rachelle W.
author_sort Omokehinde, Tolu
collection PubMed
description Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways. For example, these signals can promote the survival and dormancy of bone-disseminated cancer cells or stimulate proliferation. The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), among others. These cytokines are known to have overlapping pleiotropic functions in different cell types and are important for cross-talk between bone-resident cells. IL-6 cytokines have also been implicated in the progression and metastasis of breast, prostate, lung, and cervical cancer, highlighting the importance of these cytokines in the tumor–bone microenvironment. This review will describe the role of these cytokines in skeletal remodeling and cancer progression both within and outside of the bone microenvironment.
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spelling pubmed-70726802020-03-19 GP130 Cytokines in Breast Cancer and Bone Omokehinde, Tolu Johnson, Rachelle W. Cancers (Basel) Review Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways. For example, these signals can promote the survival and dormancy of bone-disseminated cancer cells or stimulate proliferation. The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), among others. These cytokines are known to have overlapping pleiotropic functions in different cell types and are important for cross-talk between bone-resident cells. IL-6 cytokines have also been implicated in the progression and metastasis of breast, prostate, lung, and cervical cancer, highlighting the importance of these cytokines in the tumor–bone microenvironment. This review will describe the role of these cytokines in skeletal remodeling and cancer progression both within and outside of the bone microenvironment. MDPI 2020-01-31 /pmc/articles/PMC7072680/ /pubmed/32023849 http://dx.doi.org/10.3390/cancers12020326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Omokehinde, Tolu
Johnson, Rachelle W.
GP130 Cytokines in Breast Cancer and Bone
title GP130 Cytokines in Breast Cancer and Bone
title_full GP130 Cytokines in Breast Cancer and Bone
title_fullStr GP130 Cytokines in Breast Cancer and Bone
title_full_unstemmed GP130 Cytokines in Breast Cancer and Bone
title_short GP130 Cytokines in Breast Cancer and Bone
title_sort gp130 cytokines in breast cancer and bone
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072680/
https://www.ncbi.nlm.nih.gov/pubmed/32023849
http://dx.doi.org/10.3390/cancers12020326
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