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GP130 Cytokines in Breast Cancer and Bone
Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072680/ https://www.ncbi.nlm.nih.gov/pubmed/32023849 http://dx.doi.org/10.3390/cancers12020326 |
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author | Omokehinde, Tolu Johnson, Rachelle W. |
author_facet | Omokehinde, Tolu Johnson, Rachelle W. |
author_sort | Omokehinde, Tolu |
collection | PubMed |
description | Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways. For example, these signals can promote the survival and dormancy of bone-disseminated cancer cells or stimulate proliferation. The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), among others. These cytokines are known to have overlapping pleiotropic functions in different cell types and are important for cross-talk between bone-resident cells. IL-6 cytokines have also been implicated in the progression and metastasis of breast, prostate, lung, and cervical cancer, highlighting the importance of these cytokines in the tumor–bone microenvironment. This review will describe the role of these cytokines in skeletal remodeling and cancer progression both within and outside of the bone microenvironment. |
format | Online Article Text |
id | pubmed-7072680 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70726802020-03-19 GP130 Cytokines in Breast Cancer and Bone Omokehinde, Tolu Johnson, Rachelle W. Cancers (Basel) Review Breast cancer cells have a high predilection for skeletal homing, where they may either induce osteolytic bone destruction or enter a latency period in which they remain quiescent. Breast cancer cells produce and encounter autocrine and paracrine cytokine signals in the bone microenvironment, which can influence their behavior in multiple ways. For example, these signals can promote the survival and dormancy of bone-disseminated cancer cells or stimulate proliferation. The interleukin-6 (IL-6) cytokine family, defined by its use of the glycoprotein 130 (gp130) co-receptor, includes interleukin-11 (IL-11), leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), and cardiotrophin-1 (CT-1), among others. These cytokines are known to have overlapping pleiotropic functions in different cell types and are important for cross-talk between bone-resident cells. IL-6 cytokines have also been implicated in the progression and metastasis of breast, prostate, lung, and cervical cancer, highlighting the importance of these cytokines in the tumor–bone microenvironment. This review will describe the role of these cytokines in skeletal remodeling and cancer progression both within and outside of the bone microenvironment. MDPI 2020-01-31 /pmc/articles/PMC7072680/ /pubmed/32023849 http://dx.doi.org/10.3390/cancers12020326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Omokehinde, Tolu Johnson, Rachelle W. GP130 Cytokines in Breast Cancer and Bone |
title | GP130 Cytokines in Breast Cancer and Bone |
title_full | GP130 Cytokines in Breast Cancer and Bone |
title_fullStr | GP130 Cytokines in Breast Cancer and Bone |
title_full_unstemmed | GP130 Cytokines in Breast Cancer and Bone |
title_short | GP130 Cytokines in Breast Cancer and Bone |
title_sort | gp130 cytokines in breast cancer and bone |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072680/ https://www.ncbi.nlm.nih.gov/pubmed/32023849 http://dx.doi.org/10.3390/cancers12020326 |
work_keys_str_mv | AT omokehindetolu gp130cytokinesinbreastcancerandbone AT johnsonrachellew gp130cytokinesinbreastcancerandbone |