New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?

Several clinical trials attempted to identify novel treatment options for advanced gastroesophageal tumours in first, second and further lines. Although results of targeted therapy regimens were mainly disappointing, novel immunotherapy agents showed promising activity, which led to their approval i...

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Detalles Bibliográficos
Autores principales: Puhr, Hannah Christina, Preusser, Matthias, Prager, Gerald, Ilhan-Mutlu, Aysegül
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072704/
https://www.ncbi.nlm.nih.gov/pubmed/32012895
http://dx.doi.org/10.3390/cancers12020301
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author Puhr, Hannah Christina
Preusser, Matthias
Prager, Gerald
Ilhan-Mutlu, Aysegül
author_facet Puhr, Hannah Christina
Preusser, Matthias
Prager, Gerald
Ilhan-Mutlu, Aysegül
author_sort Puhr, Hannah Christina
collection PubMed
description Several clinical trials attempted to identify novel treatment options for advanced gastroesophageal tumours in first, second and further lines. Although results of targeted therapy regimens were mainly disappointing, novel immunotherapy agents showed promising activity, which led to their approval in second and third lines in many countries. This review focuses on the results of recent clinical trials investigating novel agents including targeted therapies, immunotherapy components and chemotherapies and discuss their current impact as well as current approval status on the treatment armamentarium of advanced gastroesophageal tumours.
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spelling pubmed-70727042020-03-19 New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice? Puhr, Hannah Christina Preusser, Matthias Prager, Gerald Ilhan-Mutlu, Aysegül Cancers (Basel) Review Several clinical trials attempted to identify novel treatment options for advanced gastroesophageal tumours in first, second and further lines. Although results of targeted therapy regimens were mainly disappointing, novel immunotherapy agents showed promising activity, which led to their approval in second and third lines in many countries. This review focuses on the results of recent clinical trials investigating novel agents including targeted therapies, immunotherapy components and chemotherapies and discuss their current impact as well as current approval status on the treatment armamentarium of advanced gastroesophageal tumours. MDPI 2020-01-28 /pmc/articles/PMC7072704/ /pubmed/32012895 http://dx.doi.org/10.3390/cancers12020301 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Puhr, Hannah Christina
Preusser, Matthias
Prager, Gerald
Ilhan-Mutlu, Aysegül
New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title_full New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title_fullStr New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title_full_unstemmed New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title_short New Treatment Options for Advanced Gastroesophageal Tumours: Mature for the Current Practice?
title_sort new treatment options for advanced gastroesophageal tumours: mature for the current practice?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072704/
https://www.ncbi.nlm.nih.gov/pubmed/32012895
http://dx.doi.org/10.3390/cancers12020301
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