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Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis

Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynam...

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Autores principales: Dinu, Anca Raluca, Rogobete, Alexandru Florin, Bratu, Tiberiu, Popovici, Sonia Elena, Bedreag, Ovidiu Horea, Papurica, Marius, Bratu, Lavinia Melania, Sandesc, Dorel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072707/
https://www.ncbi.nlm.nih.gov/pubmed/32012914
http://dx.doi.org/10.3390/cells9020307
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author Dinu, Anca Raluca
Rogobete, Alexandru Florin
Bratu, Tiberiu
Popovici, Sonia Elena
Bedreag, Ovidiu Horea
Papurica, Marius
Bratu, Lavinia Melania
Sandesc, Dorel
author_facet Dinu, Anca Raluca
Rogobete, Alexandru Florin
Bratu, Tiberiu
Popovici, Sonia Elena
Bedreag, Ovidiu Horea
Papurica, Marius
Bratu, Lavinia Melania
Sandesc, Dorel
author_sort Dinu, Anca Raluca
collection PubMed
description Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. The aim of this review paper was to present, in detail, the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression.
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spelling pubmed-70727072020-03-19 Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis Dinu, Anca Raluca Rogobete, Alexandru Florin Bratu, Tiberiu Popovici, Sonia Elena Bedreag, Ovidiu Horea Papurica, Marius Bratu, Lavinia Melania Sandesc, Dorel Cells Review Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. The aim of this review paper was to present, in detail, the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression. MDPI 2020-01-28 /pmc/articles/PMC7072707/ /pubmed/32012914 http://dx.doi.org/10.3390/cells9020307 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dinu, Anca Raluca
Rogobete, Alexandru Florin
Bratu, Tiberiu
Popovici, Sonia Elena
Bedreag, Ovidiu Horea
Papurica, Marius
Bratu, Lavinia Melania
Sandesc, Dorel
Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title_full Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title_fullStr Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title_full_unstemmed Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title_short Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis
title_sort cannabis sativa revisited—crosstalk between microrna expression, inflammation, oxidative stress, and endocannabinoid response system in critically ill patients with sepsis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072707/
https://www.ncbi.nlm.nih.gov/pubmed/32012914
http://dx.doi.org/10.3390/cells9020307
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